FlyBase Allele Report: Dmel\pygo[KK108114]

General Information

Symbol

Dmel\pygo^KK108114

Species

D. melanogaster

Name

FlyBase ID

FBal0235359

Feature type

allele

Associated gene

Dmel\pygo

Associated Insertion(s)

Carried in Construct

P{KK108114}

Also Known As

pygo RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108114}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108114

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

ameliorates retinitis pigmentosa 4

modeled by ninaE^P37H.UAS

(Park et al., 2023)

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/pygo^KK108114 is a suppressor | partially of visible | adult stage phenotype of ninaE^P37H.GMR

(Park et al., 2023)

pygo^KK108114/Scer\GAL4^GMR.PU is a suppressor of increased cell death | larval stage phenotype of Scer\GAL4^GMR.PU, ninaE^P37H.UAS

(Park et al., 2023)

pygo^KK108114, Scer\GAL4^{repo.Switch.2301} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Scer\GAL4^Act.PU/pygo^KK108114 is a suppressor of hyperplasia | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/pygo^KK108114 is a suppressor | partially of eye phenotype of ninaE^P37H.GMR

(Park et al., 2023)

pygo^KK108114/Scer\GAL4^GMR.PU is a suppressor of eye disc | larval stage phenotype of Scer\GAL4^GMR.PU, ninaE^P37H.UAS

(Park et al., 2023)

Scer\GAL4^Act.PU/pygo^KK108114 is a suppressor of adult midgut | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

Scer\GAL4^Act.PU/pygo^KK108114 is a suppressor of intestinal stem cell | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of pygo^KK108114 under the control of Scer\GAL4^Act.PU suppresses the increased size of Apc2^g10 Apc^Q8 mutant intestinal stem cell clones 14 days after clone induction.

(Wang et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100724

P{KK108114}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pygo^KK108114

pygo^dsRNA

(Luo et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close