FlyBase Allele Report: Dmel\Hsc70-4[KK108223]

General Information

Symbol

Dmel\Hsc70-4^KK108223

Species

D. melanogaster

Name

FlyBase ID

FBal0235429

Feature type

allele

Associated gene

Dmel\Hsc70-4

Associated Insertion(s)

Carried in Construct

P{KK108223}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108223}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108223

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | spermatogenesis, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

lethal | paternal effect, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

visible | adult stage, with Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

interommatidial bristle, with Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

ommatidium, with Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

spermatocyte cyst, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

spermatozoon | absent, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

testis, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

Detailed Description

Statement

Reference

Expression of Hsc70-4^KK108223 under the control of Scer\GAL4^GMR.PU leads to a modest but detectable defect in external eye morphology, irregular arrangements of ommatidia and bristles, as well as reduction of the retinal depth.

(Tsuboyama et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsc70-4^KK108223, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\TARDBP^UAS.YFP, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hsc70-4^KK108223, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\TARDBP^UAS.YFP, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101734

P{KK108223}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsc70-4^IR101734

(Mukherjee et al., 2016)

Hsc70-4^KK108223

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close