FlyBase Allele Report: Dmel\Arpc1[KK108277]

General Information

Symbol

Dmel\Arpc1^KK108277

Species

D. melanogaster

Name

FlyBase ID

FBal0235467

Feature type

allele

Associated gene

Dmel\Arpc1

Associated Insertion(s)

Carried in Construct

P{KK108277}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108277}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108277

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal heat stress response | third instar larval stage, with Scer\GAL4^ppk.1.9

(Honjo et al., 2016)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.1.9

(Honjo et al., 2016)

Phenotype Manifest In

dendrite | third instar larval stage, with Scer\GAL4^ppk.1.9

(Honjo et al., 2016)

epithelium, with Scer\GAL4^NP1624

(Berns et al., 2014)

female germline cyst, with Scer\GAL4^NP1624

(Berns et al., 2014)

follicle cell | somatic clone

(Sarpal et al., 2012)

larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.1.9

(Honjo et al., 2016)

Detailed Description

Statement

Reference

Third instar larvae expressing Arpc1^KK108277 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4^ppk.1.9 display hypersensitive behavioral response (shortened latency till response to 42[o]C thermal probe stimulus) in a thermal nociception assay. Arpc1^KK108277 RNAi expression also leads to significantly decreased dendrite coverage in the ddaC dorsal multidendritic neurons compared to controls.

(Honjo et al., 2016)

Scer\GAL4^tj-NP1624-mediated expression results in holes in the cyst epithelium only detectable after stage 2 - the cyst is not covered by epithelial cells.

(Berns et al., 2014)

Clonal follicle cells expressing Arpc1^KK108277 are apically constricted, and adherens junctions appear jagged between mutant cells and between mutant and wild type cells. The phenotypes are most pronounced in stage 11 or older egg chambers.

(Sarpal et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Arpc1^KK108277 does not enhance the adherens junction phenotype seen in follicle cell clones expressing α-Cat^GD8808.

(Sarpal et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100573

P{KK108277}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Arpc1^KK108277

Sop2^KK108277

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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