FlyBase Allele Report: Dmel\Pka-C2[KK110127]

General Information

Symbol

Dmel\Pka-C2^KK110127

Species

D. melanogaster

Name

FlyBase ID

FBal0236665

Feature type

allele

Associated gene

Dmel\Pka-C2

Associated Insertion(s)

Carried in Construct

P{KK110127}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK110127}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK110127

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-208.UAS}

(Gonzales et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Pka-C2^KK110127 driven by Scer\GAL4^elav.PU does not significantly affect memory in an olfactory avoidance paradigm, compared to controls.

(Gonzales et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pka-C2^KK110127, Scer\GAL4^elav-C155 is a suppressor of partially lethal - majority die phenotype of Hsap\HTT^{128Q.1-208.UAS}, Scer\GAL4^elav-C155

(Gonzales et al., 2016)

Pka-C2^KK110127, Scer\GAL4^elav.PU is a suppressor | partially of abnormal sleep phenotype of Hsap\HTT^{128Q.1-208.UAS}, Scer\GAL4^elav.PU

(Gonzales et al., 2016)

Pka-C2^KK110127, Scer\GAL4^elav.PU is a suppressor | partially of abnormal memory | adult stage phenotype of Hsap\HTT^{128Q.1-208.UAS}, Scer\GAL4^elav.PU

(Gonzales et al., 2016)

Pka-C2^KK110127, Scer\GAL4^elav.PU is a suppressor of short lived phenotype of Hsap\HTT^{128Q.1-208.UAS}, Scer\GAL4^elav.PU

(Gonzales et al., 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Pka-C2^KK110127 suppresses lethality in flies with expression of Hsap\HTT^{128Q.1-208.Scer\UAS} driven by Scer\GAL4^elav-C155 (both the weak F27B or strong M64 insertions), partially suppresses sleep homeostasis phenotypes (both insertions, expression driven by Scer\GAL4^elav.PU) and significantly partially suppresses memory defects in the M64 line (expression driven by Scer\GAL4^elav.PU). Co-expression of Pka-C2^KK110127 significantly suppresses the shorter lifespan seen in Scer\GAL4^elav.PU>Hsap\HTT^{128Q.1-208.Scer\UAS} (F27B or M64) flies.

(Gonzales et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108424

P{KK110127}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pka-C2^KK110127

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close