FlyBase Allele Report: Dmel\Def[KK111656]

General Information

Symbol

Dmel\Def^KK111656

Species

D. melanogaster

Name

FlyBase ID

FBal0237571

Feature type

allele

Associated gene

Dmel\Def

Associated Insertion(s)

Carried in Construct

P{KK111656}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK111656}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK111656

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by dlg1^A40.2

(Parvy et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^αTub84B.PL/Def^KK111656 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^btl.PS/Def^KK111656 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/Def^KK111656 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Suppressor of

Statement

Reference

Scer\GAL4^αTub84B.PL/Def^KK111656 is a suppressor of increased cell death | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^btl.PS/Def^KK111656 is a suppressor of increased cell death | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/Def^KK111656 is a suppressor of increased cell death | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^αTub84B.PL/Def^KK111656 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^btl.PS/Def^KK111656 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/Def^KK111656 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Suppressor of

Statement

Reference

Scer\GAL4^αTub84B.PL/Def^KK111656 is a suppressor of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^btl.PS/Def^KK111656 is a suppressor of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/Def^KK111656 is a suppressor of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Expressing Def^KK111656 under the control of either Scer\GAL4^αTub84B.PL, Scer\GAL4^apolpp.PB or Scer\GAL4^btl.PS enhances the tumor phenotype of dlg1^A40.2 wing discs, while suppressing the associated apoptosis (Dcp1 staining).

(Parvy et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102437

P{KK111656}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Def^KK111656

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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