FlyBase Allele Report: Dmel\NPFR[KK112704]

General Information

Symbol

Dmel\NPFR^KK112704

Species

D. melanogaster

Name

FlyBase ID

FBal0238336

Feature type

allele

Associated gene

Dmel\NPFR

Associated Insertion(s)

Carried in Construct

P{KK112704}

Also Known As

UAS-npfr-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112704}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112704

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

female germline stem cell, with Scer\GAL4^C587

(Ameku et al., 2018)

female germline stem cell, with Scer\GAL4^e22c

(Ameku et al., 2018)

female germline stem cell, with Scer\GAL4^NP1624

(Ameku et al., 2018)

Detailed Description

Statement

Reference

Expression of NPFR^KK112704 under the control of Scer\GAL4^elav.PLu, but not Scer\GAL4^GMR71G01, in males significantly increases courtship towards males, compared to controls.

(Liu et al., 2019)

Females expressing NPFR^KK112704 under the control of Scer\GAL4^NP1624, Scer\GAL4^e22c or Scer\GAL4^C587, but not Scer\GAL4^nSyb.PP, Scer\GAL4^elav.PLu, Scer\GAL4^esg.PU, Scer\GAL4^NP0001, Scer\GAL4^Tk.PS, Scer\GAL4^nos.PG, Scer\GAL4^bab1-Gal4 or Scer\GAL4^c306, show the expected mating-induced increase in germline stem cells in the germarium, as compared to controls; the Scer\GAL4^NP1624-driven expression also leads to females failing to show the expected mating-induced increase in germline stem cell division (pH3 and BrdU labelling) and laying significantly less eggs, despite similar copulation rate, as compared to controls.

(Ameku et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107663

P{KK112704}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

NPFR1^KK112704

NPFR^KK112704

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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