FlyBase Allele Report: Dmel\tll[JF02545]

General Information

Symbol

Dmel\tll^JF02545

Species

D. melanogaster

Name

FlyBase ID

FBal0239248

Feature type

allele

Associated gene

Dmel\tll

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02545}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

(Perkins et al., 2009.8.10)

Progenitor genotype

Carried in construct

P{TRiP.JF02545}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02545

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | male limited, with Scer\GAL4^50y

(Davis et al., 2014)

abnormal behavior | male limited, with Scer\GAL4^dimm-929

(Davis et al., 2014)

abnormal behavior | male limited, with Scer\GAL4^elav-C155

(Davis et al., 2014)

abnormal behavior | male limited, with Scer\GAL4^Ilp2.PR

(Davis et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of tll^JF02545 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

Expression of tll^JF02545 in muscle under the control of Scer\GAL4^Mef2.PU results in significant hyperglycaemia.

(Ugrankar et al., 2015)

Male flies expressing tll^JF02545 under the control of Scer\GAL4^elav-C155 show increased fighting frequency compared with control animals. Increased fighting frequency is also seen when expression of tll^JF02545 is limited to the adult stages using Scer\GAL80^ts.αTub84B.

Expression of tll^JF02545 in the pars intercerebralis (PI) under the control of any of Scer\GAL4^dimm-929, Scer\GAL4^50y or Scer\GAL4^Ilp2.PR results in male flies with significantly increased fighting frequencies. In contrast, no increase in aggression is seen when tll^JF02545 is expressed in the eye (Scer\GAL4^GMR.PU), central complex (Scer\GAL4^cry.PU) or circadian LNv neurons (Scer\GAL4^c819). Increased aggression is also seen when tll^JF02545 is expressed under the control of Scer\GAL4^50y and limited to the head using Scer\GAL80^tsh-GAL80. However when tll^JF02545 is blocked with ubiquitously expressed Scer\GAL80^αTub84B.PL or pan-neuronally expressed Scer\GAL80^elav.PY there is a complete suppression of aggression.

(Davis et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^50y, tll^JF02545 has abnormal behavior | male limited phenotype, non-enhanceable by Gug^HMS00756, Scer\GAL4^50y

(Davis et al., 2014)

Suppressed by

Statement

Reference

Scer\GAL4^50y, tll^JF02545 has abnormal behavior | male limited phenotype, suppressible by amon^RNAi.UAS.cRa/Scer\GAL4^50y

(Davis et al., 2014)

Scer\GAL4^50y, tll^JF02545 has abnormal behavior | male limited phenotype, suppressible by Cadps^MB03912

(Davis et al., 2014)

Scer\GAL4^50y, tll^JF02545 has abnormal behavior | male limited phenotype, suppressible by Hsap\NR2E1^UAS.cDa, Scer\GAL4^50y

(Davis et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Gug^HMS00756 does not further enhance the increase in aggression seen when tll^JF02545 is expressed under the control of Scer\GAL4^50y.

Expression of amon^{dsRNA.Scer\UAS.cBa} fully suppresses the increase in male aggression seen when tll^JF02545 is expressed under the control of Scer\GAL4^50y.

Homozygous Caps^MB03912 fully suppresses the increase in male aggression seen when tll^JF02545 is expressed under the control of Scer\GAL4^50y.

(Davis et al., 2014)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\NR2E1^Scer\UAS.cDa strongly suppresses the increase in aggression seen when tll^JF02545 is expressed under the control of Scer\GAL4^50y.

(Davis et al., 2014)

Complementation and Rescue Data

Rescued by

tll^JF02545 is rescued by tll^UAS.cDa/Scer\GAL4^50y

(Davis et al., 2014)

Comments

Expression of tll^Scer\UAS.cDa strongly suppresses the increase in aggression seen when tll^JF02545 is expressed under the control of Scer\GAL4^50y.

(Davis et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27242

y¹ v¹; P{TRiP.JF02545}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tll^JF02545

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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