FlyBase Allele Report: Dmel\CanB[JF02616]

General Information

Symbol

Dmel\CanB^JF02616

Species

D. melanogaster

Name

FlyBase ID

FBal0239316

Feature type

allele

Associated gene

Dmel\CanB

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02616}

Also Known As

UAS-CaNB-RNAi, UAS-CanB RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

(Perkins et al., 2009.8.10)

Progenitor genotype

Carried in construct

P{TRiP.JF02616}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02616

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Shaw et al., 2015, Shaw and Chang, 2013)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Shao et al., 2022)

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of CanB^JF02616 under the control of Scer\GAL4^GMR.PU does not cause any adult eye phenotype compared to controls.

(Lee et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CanB^JF02616, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^GMR.PU

(Lee et al., 2016)

Suppressor of

Statement

Reference

CanB^JF02616, Scer\GAL4^c739 is a suppressor | partially of abnormal memory | adult stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^c739

(Shaw et al., 2015)

CanB^JF02616, Scer\GAL4^elav.PU is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

CanB^JF02616, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^GMR.PU

(Lee et al., 2016)

Suppressor of

Statement

Reference

CanB^JF02616, Scer\GAL4^elav.PU is a suppressor of axon | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

CanB^JF02616, Scer\GAL4^elav.PU is a suppressor of synaptic vesicle | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The small and rough eye phenotype observed in flies expressing Hsap\APP^{Aβ42.Scer\UAS.cBa} under the control of Scer\GAL4^GMR.PU is exacerbated further by co-expression of CanB^JF02616 RNAi.

(Lee et al., 2016)

Co-expression of CanB^JF02616 significantly rescues the short term memory defects of flies expressing Hsap\APP^{695.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^c739.

(Shaw et al., 2015)

Co-expression of CanB^JF02616 reduces Syt1 aggregate accumulations at NMJ axons and restores locomotor behavior in Scer\GAL4^elav.PU>Hsap\APP^{695.Scer\UAS.T:Hsap\MYC} larvae.

(Shaw and Chang, 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27307

y¹ v¹; P{TRiP.JF02616}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CanB^JF02616

CanB^RNAi#1

(Weiss et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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