FlyBase Allele Report: Dmel\aurB[JF03107]

General Information

Symbol

Dmel\aurB^JF03107

Species

D. melanogaster

Name

FlyBase ID

FBal0239607

Feature type

allele

Associated gene

Dmel\aurB

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03107}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03107}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03107

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates pancreatic ductal adenocarcinoma

modeled by CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | larval stage, with Scer\GAL4^Hml.Δ

(Luo et al., 2025)

hypoplasia, with Scer\GAL4^mirr-DE

(Wang et al., 2015)

Phenotype Manifest In

embryonic/larval crystal cell | decreased number | larval stage, with Scer\GAL4^Hml.Δ

(Luo et al., 2025)

eye disc | larval stage, with Scer\GAL4^mirr-DE

(Wang et al., 2015)

Detailed Description

Statement

Reference

Expression of aurB^JF03107 under the control of Scer\GAL4^mirr-DE attenuates larval eye disc growth.

Expression of aurB^JF03107 under the control of Scer\GAL4^e22c does not alter the number of nuclei in the central syncytium that forms around a puncture wound in the epidermis of third instar larvae, nor does it induce syncytia formation in unwounded epithelium.

(Wang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Hml.Δ, aurB^JF03107 has decreased cell number | larval stage phenotype, non-enhanceable by PpV^KK108896/Scer\GAL4^lz-gal4

(Luo et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^Hml.Δ, aurB^JF03107 has decreased cell number | larval stage phenotype, non-suppressible by PpV^KK108896/Scer\GAL4^lz-gal4

(Luo et al., 2025)

Suppressor of

Statement

Reference

aurB^JF03107, Scer\GAL4^Ser.PU is a suppressor | partially of increased mortality during development phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^Ser.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Scer\GAL4^ptc.PU, aurB^JF03107 is a suppressor | partially of increased size | larval stage phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^ptc.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

NOT Suppressor of

Statement

Reference

aurB^JF03107/Scer\GAL4^e22c is a non-suppressor of abnormal cell shape | third instar larval stage phenotype of Scer\GAL4^e22c, stck^NIG.7954R

(Wang et al., 2015)

aurB^JF03107/Scer\GAL4^e22c is a non-suppressor of increased cell size | third instar larval stage phenotype of Scer\GAL4^e22c, stck^NIG.7954R

(Wang et al., 2015)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Hml.Δ, aurB^JF03107 has embryonic/larval crystal cell | larval stage | decreased number phenotype, non-enhanceable by PpV^KK108896/Scer\GAL4^lz-gal4

(Luo et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^Hml.Δ, aurB^JF03107 has embryonic/larval crystal cell | larval stage | decreased number phenotype, non-suppressible by PpV^KK108896/Scer\GAL4^lz-gal4

(Luo et al., 2025)

Suppressor of

Statement

Reference

Scer\GAL4^ptc.PU, aurB^JF03107 is a suppressor of wing disc phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^ptc.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

NOT Suppressor of

Statement

Reference

aurB^JF03107/Scer\GAL4^e22c is a non-suppressor of embryonic/larval epidermis | third instar larval stage phenotype of Scer\GAL4^e22c, stck^NIG.7954R

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of abnormal large syncytia in larval epidermis characteristic for third instar larvae expressing stck^NIG.7954R under the control of Scer\GAL4^e22c is not suppressed by co-expression of any of aurB^JF03107.

(Wang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28691

y¹ v¹; P{TRiP.JF03107}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

aurB^JF03107

ial^JF03107

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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