FB2025_05 , released December 11, 2025
Allele: Dmel\ykiS250A.UAS.Tag:V5
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General Information
Symbol
Dmel\ykiS250A.UAS.Tag:V5
Species
D. melanogaster
Name
FlyBase ID
FBal0239735
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
Carried in Construct
P{UAS-yki.S250A.V5}
Key Links
Transgenic product class
missense_variant
(Oh and Irvine, 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Oh and Irvine, 2009)
Mutagen
in vitro construct
(Oh and Irvine, 2009)
Progenitor genotype
Carried in construct
P{UAS-yki.S250A.V5}
Cytology
Description

Amino acid replacement: S250A.

(Oh and Irvine, 2009)

UAS regulatory sequences drive expression of a mutated form of yki which is tagged with Tag:V5.

(Oh and Irvine, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
yki
Tagged with
Tag:V5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wing disc clones expressing ykiS250A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4Scer\FRT.Act5C induce growth enhancement.

      (Oh and Irvine, 2011)

      Expression of ykiS250A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GMR.PF results in an increase in eye size.

      Expression of ykiS250A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4sd-SG29.1 results in enlarged wings.

      (Oh and Irvine, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      ykiS250A.UAS.Tag:V5 has wing disc | somatic clone phenotype, suppressible by Mad12

      (Oh and Irvine, 2011)
      Suppressor of
      Statement
      Reference

      Scer\GAL4FRT.Act5C/ykiS250A.UAS.Tag:V5 is a suppressor of wing disc | somatic clone phenotype of Mad12

      (Oh and Irvine, 2011)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Mad12 mutant background suppresses the overgrowth seen when ykiS250A.Scer\UAS.T:SV5\V5 is expressed in wing disc clones under the control of Scer\GAL4Scer\FRT.Act5C, returning the number of cells to control levels.

      (Oh and Irvine, 2011)

      Co-expression of ykiS250A.Scer\UAS.T:SV5\V5 and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PF results in flies with small eyes.

      (Oh and Irvine, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ykiS250A.Scer\UAS.T:SV5\V5
      ykiS250A.UAS.Tag:V5
      Name Synonyms
      Secondary FlyBase IDs
        References (3)