FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ykiS111A.S168A.UAS.Tag:V5
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General Information
Symbol
Dmel\ykiS111A.S168A.UAS.Tag:V5
Species
D. melanogaster
Name
FlyBase ID
FBal0239741
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
Carried in Construct
P{UAS-yki.S111A.S168A.V5}
Key Links
Transgenic product class
missense_variant
(Oh and Irvine, 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Oh and Irvine, 2009)
Mutagen
in vitro construct
(Oh and Irvine, 2009)
Progenitor genotype
Carried in construct
P{UAS-yki.S111A.S168A.V5}
Cytology
Description

Amino acid replacement: S111A.

(Oh and Irvine, 2009)

UAS regulatory sequences drive expression of a mutated form of yki which is tagged with Tag:V5.

(Oh and Irvine, 2009)

Amino acid replacement: S168A.

(Oh and Irvine, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
yki
Tagged with
Tag:V5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ykiS111A.S168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GMR.PF results in a greatly enlarged and folded eye, and viability is reduced.

      Expression of ykiS111A.S168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4sd-SG29.1 results in an extended third instar larval stage and eventual late larval lethality.

      (Oh and Irvine, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of ykiS111A.S168A.Scer\UAS.T:SV5\V5 and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PF results in flies with greatly enlarged eyes (but less so than in the absence of hpoScer\UAS.T:Zzzz\FLAG).

      Co-expression of ykiS111A.S168A.Scer\UAS.T:SV5\V5, wtsScer\UAS.T:Hsap\MYC and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PF results in flies with greatly enlarged eyes (but less so than in the absence of wtsScer\UAS.T:Hsap\MYC and hpoScer\UAS.T:Zzzz\FLAG).

      (Oh and Irvine, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ykiS111A.S168A.Scer\UAS.T:SV5\V5
      ykiS111A.S168A.UAS.Tag:V5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)