FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RhoGEF64CBG00336
Open Close
General Information
Symbol
Dmel\RhoGEF64CBG00336
Species
D. melanogaster
Name
FlyBase ID
FBal0239822
Feature type
allele
Associated gene
Dmel\RhoGEF64C
Associated Insertion(s)
P{GT1}RhoGEF64CBG00336
Carried in Construct
Also Known As
BG00336
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GT1}RhoGEF64CBG00336
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GT1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Male and female Gef64CBG00336 mutants show an increased lifespan compared to controls.

        Starvation response is reduced in both males and females at 1 week and 6 weeks.

        Chill coma recovery time in both males and females is increased compared to controls at one week. Recovery time at 6 weeks is similar to controls in females but is reduced in males.

        No change in climbing ability is seen in females at either 1 week or 6 weeks. Males have improved climbing ability compared to controls at 6 weeks but not at 1 week.

        (Magwire et al., 2010)

        Gef64CBG00336 homozygous males have significantly decreased levels of aggression. (P < 0.0001; Male aggression index = 6.1).

        (Edwards et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Gef64CBG00336
        RhoGEF64CBG00336
        Name Synonyms
        Secondary FlyBase IDs
          References (2)