FB2026_02 , released June 18, 2026
Allele: Dmel\hbs66
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General Information
Symbol
Dmel\hbs66
Species
D. melanogaster
Name
FlyBase ID
FBal0239852
Feature type
allele
Associated gene
Dmel\hbs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Grillo-Hill and Wolff, 2009)
Mutagen
X ray
(Grillo-Hill and Wolff, 2009)
Progenitor genotype
Caused by aberration
In(2R)66
Cytology
Description

Deletion of nucleotide T620 leads to a frameshift predicted to prematurely truncate hbs.

(Grillo-Hill and Wolff, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:15,036,168..15,036,168 [+]
Comment:

A deletion of a T nucleotide in the second exon of hbs causes a frameshift and early translation termination.

(Grillo-Hill and Wolff, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hbs66/hbsa69, hbs66/hbs361, hbs66/hbs459, hbs66/hbs1130 or hbs66/hbs2593 eyes exhibit reduced number of Rh5 expressing R8 cells.

      Eye specific clones of hbs66 exhibit a dramatic decrease in Rh5 expression and mispairing of Rh3 and Rh6 in adjacent R7 and R8 cells of individual ommatidia.

      (Tan et al., 2020)

      hbs66/hbs66, hbs66/hbs459 and hbs66/hbs2593 adults have rough eyes.

      hbs66/hbs66 and hbs66/Df(2R)δ12 pupal/pharate adult animals have a low incidence of fused ommatidia and wrong numbers of cone cells per ommatidium (<5% ommatidia) and a higher incidence of abnormal contacts between cone cells (35-40% ommatidia). Adults have a low incidence of tissue polarity defects (<3% ommatidia).

      (Grillo-Hill and Wolff, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hbs66
      (Li et al., 2026, Tan et al., 2020, Grillo-Hill and Wolff, 2009)
      icon66
      (Grillo-Hill and Wolff, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)