FB2026_02 , released June 18, 2026
Allele: Dmel\hbsEP
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General Information
Symbol
Dmel\hbsEP
Species
D. melanogaster
Name
FlyBase ID
FBal0239854
Feature type
allele
Associated gene
Dmel\hbs
Associated Insertion(s)
P{Mae-GMR.EP}hbsEP
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{Mae-GMR.EP}hbsEP
    Cytology
    Description

    P{Mae-GMR.EP} inserted immediately upstream of the transcription start site of hbs.

    (Grillo-Hill and Wolff, 2009)
    Allele components
    Component
    Use(s)
    Inserted element
    P{Mae-GMR.EP}
    Regulatory region(s)
    GMR
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        hbsEP/hbsEP and hbsEP/Df(2R)δ12 pupal/pharate adult animals have a low incidence of fused ommatidia and wrong numbers of cone cells per ommatidium (<5% ommatidia) and a higher incidence of abnormal contacts between cone cells (50-60% ommatidia). These abnormal contacts reflect arrested cone cell morphogenesis: many cone cells maintain juvenile morphology and cell contacts in the adult. Adherens junctions between these cone cells appear normal, suggesting that this phenotype is not due to some general defect in junction formation or maintenance. These cone cell defects are also caused by somatic clones of hbsEP homozygous cells in the developing retina. The effect is autonomous to individual ommatidia: all ommatidia with defective cone cell contacts have at least one cone cell that is mutant.

        hbsEP/hbsEP adults also have a low incidence of tissue polarity defects (<4% ommatidia) and occasional extra-interommatidial cells including extra interommatidial bristles. Thoracic microchaetae are also mis-patterned, leading to bald patches.

        (Grillo-Hill and Wolff, 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        hbsEP
        (Singh and Mlodzik, 2012, Grillo-Hill and Wolff, 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)