FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-184UAS.cIa
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General Information
Symbol
Dmel\mir-184UAS.cIa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Iovino
FlyBase ID
FBal0239920
Feature type
allele
Associated gene
Dmel\mir-184
Associated Insertion(s)
Carried in Construct
P{UAS-mir-184.I}
Also Known As
UAS-mir-184
Key Links
Transgenic product class
wild_type
(Iovino et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Iovino et al., 2009)
Mutagen
in vitro construct
(Iovino et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-mir-184.I}
Cytology
Description

UASt regulatory sequences drive expression of a 1.5kb genomic fragment containing mir-184 (contains 1kb of upstream and 0.5kb of downstream sequences).

(Iovino et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mir-184
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing mir-184UAS.cIa under the control of Scer\GAL4Tub.Switch.PU significantly reduces the adult life span of males and females treated with RU486 (to switch on transgene expression) under both low- and high-nutrient diets compared to untreated controls.

      (Gendron and Pletcher, 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      mir-184UAS.cIa, Scer\GAL4ap.PU is a suppressor of wing disc phenotype of GliUAS.cSa, Scer\GAL4ap.PU

      (Sharifkhodaei et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of mir-184Scer\UAS.cIa suppresses the migration of wing disc cells expressing GliScer\UAS.cSa under the control of Scer\GAL4ap.PU into the non-expressing side of the disc.

      (Sharifkhodaei et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      mir-184UAS.cIa partially rescues mir-184Δ

      (Iovino et al., 2009)

      mir-184UAS.cIa/Scer\GAL4VP16.nanos.UTR partially rescues mir-184Δ

      (Iovino et al., 2009)
      Comments

      Expression of mir-184Scer\UAS.cIa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 strongly rescues the sterility of mir-184Δ females; egg production approaches normal levels and almost all eggs and embryos appear morphologically normal.

      Substantial rescue of egg production, but not egg morphology, is seen in mir-184Δ females carrying mir-184Scer\UAS.cIa in the absence of a Scer\GAL4 driver.

      (Iovino et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mir-184Scer\UAS.cIa
      mir-184UAS.cIa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Iovino
      Secondary FlyBase IDs
        References (5)