FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AntpAAAA.UAS
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General Information
Symbol
Dmel\AntpAAAA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0239936
Feature type
allele
Associated gene
Dmel\Antp
Associated Insertion(s)
Carried in Construct
P{UAS-Antp.AAAA}
Key Links
Transgenic product class
missense_variant
(Prince et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Prince et al., 2008)
Mutagen
in vitro construct
(Prince et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Antp.AAAA}
Cytology
Description

Amino acid replacement: Y?A.

(Prince et al., 2008)

UAS regulatory sequences drive expression of Antp coding sequences in which the YPWM motif is replaced by four alanines.

(Prince et al., 2008)

Amino acid replacement: P?A.

(Prince et al., 2008)

Amino acid replacement: W?A.

(Prince et al., 2008)

Amino acid replacement: M?A.

(Prince et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Antp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      AntpAAAA.UAS/Scer\GAL4ey.PH is an enhancer of wing | ectopic phenotype of Nact.sev

      (Prince et al., 2008)

      AntpAAAA.UAS/Scer\GAL4ey.PH is an enhancer of eye phenotype of Nact.sev

      (Prince et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Approximately 20% of Scer\GAL4ey.PH; Nact.sev; AntpAAAA.Scer\UAS flies exhibit antenna-to-leg transformation, while none of these flies show eye-to-wing transformation. Legs induced in this fashion exhibit second leg identity, growing tibial apical bristles.

      Co-expression of exdScer\UAS.cGa in combination with AntpAAAA.Scer\UAS in the presence of Nact.sev all under the control of Scer\GAL4ey.PH results in approximately 2% of flies exhibiting wing structures in the eye region, compared to around 40% when exdScer\UAS.cGa is absent. Only 3% of these flies show antenna-to-leg transformation compared with 28% without exdScer\UAS.cGa. The presence of exdScer\UAS.cGa also inhibits antenna-to-leg transformation induced by AntpAAAA.Scer\UAS from 19% to 4.5% (in a Nact.sev and Scer\GAL4ey.PH background).

      (Prince et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AntpAAAA.Scer\UAS
      AntpAAAA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)