FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MiroUAS.Tag:MYC
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General Information
Symbol
Dmel\MiroUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0240157
Feature type
allele
Associated gene
Dmel\Miro
Associated Insertion(s)
Carried in Construct
P{UAS-Miro.Myc}
Key Links
Transgenic product class
cDNA
(Russo et al., 2009)
wild_type
(Russo et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Russo et al., 2009)
wild_type
(Russo et al., 2009)
Mutagen
in vitro construct
(Russo et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Miro.Myc}
Cytology
Description

UASt sequences govern expression of Miro cDNA in which the Miro ORF is fused at the N-terminal to the epitope tag Tag:MYC.

(Russo et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Miro
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Lee et al., 2018)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease 6
      modeled by Pink1B9
      (Lee et al., 2018)
      model of  Parkinson's disease
      is ameliorated by MCUHMS01927
      (Lee et al., 2018)
      is ameliorated by MarfRNAi.cUa.UAS
      (Lee et al., 2018)
      is ameliorated by poloGD7563
      (Lee et al., 2018)
      is ameliorated by poloS025604
      (Lee et al., 2018)
      is ameliorated by porinJF03251
      (Lee et al., 2018)
      is ameliorated by ItprJF01957
      (Lee et al., 2018)
      is ameliorated by MarfRNAi.UAS.cUa
      (Lee et al., 2018)
      exacerbates  Parkinson's disease 8
      modeled by Hsap\LRRK2G2019S.UAS.cUa
      (Lee et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      mitochondrion & motor neuron | larval stage, with Scer\GAL4RapGAP1-OK6

      (Russo et al., 2009)
      Detailed Description
      Statement
      Reference

      The proportion of mitochondria that are motile is reduced in the motor neurons of MiroScer\UAS.T:Hsap\MYC; Scer\GAL4OK6 larvae, as is the number of stationary clusters of mitochondria in these cells. Both anterograde and retrograde flux of mitochondria in motor neuron axons is reduced. In addition, anterograde motile mitochondria are significantly longer than wild-type. This effect is not seen with retrograde motile mitochondria.

      (Russo et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4RapGAP1-OK6/MiroUAS.Tag:MYC partially rescues MiroSd32/MiroB682

      (Russo et al., 2009)
      Comments

      MiroScer\UAS.T:Hsap\MYC; Scer\GAL4OK6 largely rescues the reduction in the number motile mitochondria and the decreased mitochondrial flux seen in axons of motor neurons of MiroB682/MiroSd32 larvae, however, the reduction of stationary mitochondrial clusters is not rescued. Rescue is more complete at 20'C than at 25'C.

      (Russo et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MiroScer\UAS.T:Hsap\MYC
      MiroUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)