FlyBase Allele Report: Dmel\sgl[BG01214]

General Information

Symbol

Dmel\sgl^BG01214

Species

D. melanogaster

Name

FlyBase ID

FBal0240210

Feature type

allele

Associated gene

Dmel\sgl

Associated Insertion(s)

P{GT1}sgl^BG01214

Carried in Construct

Also Known As

BG01214

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GT1}sgl^BG01214

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GT1}

gene trap

polyA trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Edwards et al., 2009)

abnormal smell perception

(Sambandan et al., 2006)

viable

(Sambandan et al., 2006)

Phenotype Manifest In

adult mushroom body alpha'-lobe

(Edwards et al., 2009)

adult mushroom body alpha-lobe

(Edwards et al., 2009)

adult mushroom body beta'-lobe

(Edwards et al., 2009)

adult mushroom body beta-lobe

(Edwards et al., 2009)

Detailed Description

Statement

Reference

sgl^BG01214 homozygous males have significantly increased levels of aggression. (P < 0.0001; Male aggression index = 17.1). They also have mushroom body defects including significantly shorter and wider alpha-lobes and, in some cases, fusion of the beta-lobes.

(Edwards et al., 2009)

sgl^BG01214 mutant females have reduced glycogen levels compared to wild type controls. No change is seen in males. sgl^BG01214 mutant males have reduced triglyceride levels compared to wild type controls. No change is seen in males.

(Harbison and Sehgal, 2008)

Mutants show an abnormal olfactory avoidance response to 0.3% benzaldehyde.

(Sambandan et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of P{GT1}sgl^BG01214 reverts the increased aggression phenotype seen in sgl^BG01214 homozygotes.

(Edwards et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

BG01214

(Sambandan et al., 2006)

BG01214^BG01214

sgl^BG01214

Name Synonyms

Secondary FlyBase IDs

FBal0195598
FBal0239841

References (4)

Report Sections

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