FB2026_02 , released June 18, 2026
Allele: Dmel\vgUAS.Tag:HA
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General Information
Symbol
Dmel\vgUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0240570
Feature type
allele
Associated gene
Dmel\vg
Associated Insertion(s)
Carried in Construct
P{UAS-vg.3xHA}
Key Links
Transgenic product class
wild_type
(Deng et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Deng et al., 2009)
Mutagen
in vitro construct
(Deng et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-vg.3xHA}
Cytology
Description

UAS regulatory sequences drive expression of vg which is tagged with Tag:HA.

(Deng et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
vg
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectopic expression of vgScer\UAS.T:Ivir\HA1 within the lateral transverse (LT)1-4 muscles (under the control of Scer\GAL4Mef2.PR) causes them to migrate toward the segment borders and attach there, producing muscle-muscle attachments between LT and VA muscles, where they normally do not occur. This ectopic expression does not seem to alter the initial muscle identities of LT2, LT4, and ventral acute muscle 2. The ectopic muscle-muscle adhesions induced by ectopic expression of vgScer\UAS.T:Ivir\HA1 in the LT muscles seems to be functional, because muscle VA1 is often located away from its normal position due to tension produced by abnormal attachment to the LT muscles.

      (Deng et al., 2010)

      Expression of vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR does not affect the formation of the midgut constrictions in the embryo.

      Expression of vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR results in the loss of muscles VO4-VO6, although the overall organisation of the remaining muscles appears normal.

      Expression of vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR does not affect the Mef2-positive cardiac cells, but causes two additional tin-positive cardiac cells per hemisegment.

      (Deng et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      Scer\GAL4Mef2.PR/vgUAS.Tag:HA is an enhancer of muscle attachment site | ectopic phenotype of sli2

      (Deng et al., 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The muscle detachment phenotype found in vgnull; rhea1 double mutant embryos appears to be solely due to a lack of vg activity as it can be rescued through expression of vgScer\UAS.T:Ivir\HA1 in muscle cells.

      Co-expression of both vgScer\UAS.T:Ivir\HA1 and sdΔ88-159.Scer\UAS in developing muscles under the control of Scer\GAL4Mef2.PR results in fewer ectopic muscle attachments (24.5% compared with 81.8% when vgScer\UAS.T:Ivir\HA1 is expressed alone).

      (Deng et al., 2010)

      Embryos co-expressing vgScer\UAS.T:Ivir\HA1 and sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR show complete disruption of the organisation of muscle fibres and muscle cell attachment.

      Co-expression of vgScer\UAS.T:Ivir\HA1 and Mef2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR in the embryo has a synergistic effect on cardiac cells; there are two extra rows of Mef2-positive cardiac cells and six tin-positive cardiac cells per hemisegment, with many more tin-positive pericardial cells.

      Co-expression of sdScer\UAS.T:Zzzz\FLAG and vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR in the embryo results in the loss of almost all Mef2-positive cardiac cells and dislocation of all tin-positive cells into the somatic muscle region.

      (Deng et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      vgScer\UAS.T:Ivir\HA1
      vgUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)