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General Information
Symbol
Dmel\vgUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0240570
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of vg which is tagged with Tag:HA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ectopic expression of vgScer\UAS.T:Ivir\HA1 within the lateral transverse (LT)1-4 muscles (under the control of Scer\GAL4Mef2.PR) causes them to migrate toward the segment borders and attach there, producing muscle-muscle attachments between LT and VA muscles, where they normally do not occur. This ectopic expression does not seem to alter the initial muscle identities of LT2, LT4, and ventral acute muscle 2. The ectopic muscle-muscle adhesions induced by ectopic expression of vgScer\UAS.T:Ivir\HA1 in the LT muscles seems to be functional, because muscle VA1 is often located away from its normal position due to tension produced by abnormal attachment to the LT muscles.

Expression of vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR does not affect the formation of the midgut constrictions in the embryo.

Expression of vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR results in the loss of muscles VO4-VO6, although the overall organisation of the remaining muscles appears normal.

Expression of vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR does not affect the Mef2-positive cardiac cells, but causes two additional tin-positive cardiac cells per hemisegment.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The muscle detachment phenotype found in vgnull; rhea1 double mutant embryos appears to be solely due to a lack of vg activity as it can be rescued through expression of vgScer\UAS.T:Ivir\HA1 in muscle cells.

Co-expression of both vgScer\UAS.T:Ivir\HA1 and sdΔ88-159.Scer\UAS in developing muscles under the control of Scer\GAL4Mef2.PR results in fewer ectopic muscle attachments (24.5% compared with 81.8% when vgScer\UAS.T:Ivir\HA1 is expressed alone).

Embryos co-expressing vgScer\UAS.T:Ivir\HA1 and sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR show complete disruption of the organisation of muscle fibres and muscle cell attachment.

Co-expression of vgScer\UAS.T:Ivir\HA1 and Mef2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR in the embryo has a synergistic effect on cardiac cells; there are two extra rows of Mef2-positive cardiac cells and six tin-positive cardiac cells per hemisegment, with many more tin-positive pericardial cells.

Co-expression of sdScer\UAS.T:Zzzz\FLAG and vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR in the embryo results in the loss of almost all Mef2-positive cardiac cells and dislocation of all tin-positive cells into the somatic muscle region.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
vgScer\UAS.T:Ivir\HA1
vgUAS.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (2)