FB2026_02 , released June 18, 2026
Allele: Dmel\sdUAS.Tag:FLAG
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General Information
Symbol
Dmel\sdUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0240569
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
Carried in Construct
P{UAS-sd.3xFLAG}
Key Links
Transgenic product class
wild_type
(Deng et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Deng et al., 2009)
Mutagen
in vitro construct
(Deng et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-sd.3xFLAG}
Cytology
Description

UAS regulatory sequences drive expression of sd which is tagged with Tag:FLAG.

(Deng et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sd
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4sd-SG29.1 does not cause any changes to the somatic or cardiac muscle specification in embryos.

      Expression of sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR results in the loss of all three midgut constrictions in the embryo.

      Embryos expressing sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR have disorganised somatic muscles. Muscle LL1 either does not develop well or is lost, and muscles VL1-VL2 are often missing in many segments. Ventral muscles VO4-VO6 are still present, but they have more projections than seen in wild-type embryos and some projections expand anterior-ventrally.

      Expression of sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR causes two extra rows of Mef2-positive cardiac cells, whereas the total number of tin-positive cardiac cells is similar to wild type. However, the pattern of differentiating cardiac cells is disorganised, with some tin-positive cells being seen in the somatic muscle region.

      (Deng et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos co-expressing vgScer\UAS.T:Ivir\HA1 and sdScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR show complete disruption of the organisation of muscle fibres and muscle cell attachment.

      Co-expression of sdScer\UAS.T:Zzzz\FLAG and Mef2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR in the embryo results in a cardiac cell phenotype similar to that of embryos expressing sdScer\UAS.T:Zzzz\FLAG alone under the control of Scer\GAL4Mef2.PR.

      Co-expression of sdScer\UAS.T:Zzzz\FLAG and vgScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mef2.PR in the embryo results in the loss of almost all Mef2-positive cardiac cells and dislocation of all tin-positive cells into the somatic muscle region.

      (Deng et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sdScer\UAS.T:Zzzz\FLAG
      sdUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)