FlyBase Allele Report: Dmel\sxc[02637]

General Information

Symbol

Dmel\sxc⁰²⁶³⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0240658

Feature type

allele

Associated gene

Dmel\sxc

Associated Insertion(s)

Transpac{}sxc⁰²⁶³⁷

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

Transpac{}sxc⁰²⁶³⁷

Cytology

Description

sxc⁰²⁶³⁷ is caused by an insertion of a large Transpac transposable element within the first exon of sxc.

(Sinclair et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Sinclair et al., 2009)

lethal (with sxc³)

(Sinclair et al., 2009)

lethal | recessive

(Spradling et al., 1999, Jackle and Janning, 1998.8.10)

majority die during embryonic stage | maternal effect | heat sensitive (with sxc¹), with Scer\GAL4^da.G32, sxc^UAS.cSa

(Radermacher et al., 2014)

Phenotype Manifest In

wing vein | ectopic (with sxc³), with Scer\GAL4^Tub.PU, sxc^UAS.cSa

(Sinclair et al., 2009)

Detailed Description

Statement

Reference

Embryos derived from sxc¹/sxc⁰²⁶³⁷ females expressing sxc^Scer\UAS.cSa under the control of Scer\GAL4^da.G32 show a dramatic reduction in the hatching rate compared to controls at 34[o]C.

(Radermacher et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

sxc³/sxc⁰²⁶³⁷ has lethal phenotype, suppressible by Hsap\OGT^UAS.cSa/Scer\GAL4^Tub.PU

(Sinclair et al., 2009)

Phenotype Manifest In

Other

Statement

Reference

Hsap\OGT^UAS.cSa, Scer\GAL4^Tub.PU, sxc³/sxc⁰²⁶³⁷ has wing vein | ectopic phenotype

(Sinclair et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\OGT^Scer\UAS.cSa under the control of Scer\GAL4^tub rescues the lethality of sxc³/sxc⁰²⁶³⁷.

(Sinclair et al., 2009)

Complementation and Rescue Data

Rescued by

sxc³/sxc⁰²⁶³⁷ is rescued by Scer\GAL4^Tub.PU/sxc^UAS.cSa

(Sinclair et al., 2009)

Comments

Expression of sxc^Scer\UAS.cSa under the control of Scer\GAL4^tub rescues the lethality of sxc³/sxc⁰²⁶³⁷.

(Sinclair et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: CG46146⁰²⁶³⁷.

(Sinclair et al., 2009)

The "l(2)02637" line contains the viable P{PZ}CG46146⁰²⁶³⁷ insertion in the CG46146 gene, resulting in the viable CG46146⁰²⁶³⁷ allele, and also contains the lethal Transpac{}sxc⁰²⁶³⁷ insertion in the sxc gene, resulting in the lethal sxc⁰²⁶³⁷ allele.

(Sinclair et al., 2009)

Comments

FlyBase Curator comment: Added "l(2)02637[02637]" symbol synonym to sxc⁰²⁶³⁷ as FBrf0209489 states that the lethality associated with the "l(2)02637" line is caused by a second lesion, the Transpac{}sxc⁰²⁶³⁷ insertion, in the sxc gene and not the P{PZ}L⁰²⁶³⁷ insertion in the L gene.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

P1201

(Dickson et al., 1995)

l (2)02637

(Sinclair et al., 2009, Sinclair et al., 2009)

l(2)02637

(Spradling et al., 1999)

l(2)02637⁰²⁶³⁷

(Jackle and Janning, 1998.8.10)

sxc(Ogt)²⁶³⁷

(Radermacher et al., 2014)

sxc⁰²⁶³⁷

sxc²⁶³⁷

(Radermacher et al., 2014, Sinclair et al., 2009, Sinclair et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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