FB2026_02 , released June 18, 2026
Allele: Dmel\NT1Cysknot.UAS
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General Information
Symbol
Dmel\NT1Cysknot.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0240740
Feature type
allele
Associated gene
Dmel\NT1
Associated Insertion(s)
Carried in Construct
P{UAS-NT1.Cysknot}
Key Links
Transgenic product class
inframe_deletion
(Zhu et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zhu et al., 2008)
Mutagen
in vitro construct
(Zhu et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-NT1.Cysknot}
Cytology
Description

UAS regulatory sequences drive expression of NT1 coding sequences corresponding to the Cystine-knot region.

(Zhu et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
NT1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPArctic.UAS.Tag:SS(nec)
      (Lim et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of NT1Cysknot.Scer\UAS under the control of Scer\GAL4elav-C155 improves the longevity of adult flies: their median survival is significantly increased compared to controls at both 25[o]C and 29[o]C. However, the locomotor ability (climbing velocity) of adult flies is not significantly different from wild-type controls and also does not decline with age more than in wild-type.

      (Lim et al., 2015)

      Expression of NT1Cysknot.Scer\UAS in the embryonic nervous system under the control of Scer\GAL4elav-C155 results in a significant reduction in apoptosis levels compared to wild-type.

      Expression of NT1Cysknot.Scer\UAS in the embryonic nervous system midline under the control of Scer\GAL4sim.PS results in a significant reduction in apoptosis levels compared to wild-type, implying that NT1 is normally present in limiting amounts at this target.

      (Zhu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The short lifespan of adult flies expressing Hsap\APPArctic.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav-C155 (cultured at either 25[o]C or 29[o]C) is significantly lengthened by co-expression of NT1Cysknot.Scer\UAS. The impaired locomotor ability of Hsap\APPArctic.Scer\UAS.T:SS-nec expressing adults is also partially ameliorated by co-expression of NT1Cysknot.Scer\UAS.

      (Lim et al., 2015)
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/NT1Cysknot.UAS rescues NT141

      (Zhu et al., 2008)
      Comments

      Expression of NT1Cysknot.Scer\UAS in all neurons (under the control of Scer\GAL4elav-C155) in embryos mutant for NT141 leads to a significant reduction in apoptosis compared to NT141 mutants.

      (Zhu et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NT1Cysknot.Scer\UAS
      NT1Cysknot.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)