FB2026_03 , released September 17, 2026
Allele: Dmel\Snmp1Z0429
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General Information
Symbol
Dmel\Snmp1Z0429
Species
D. melanogaster
Name
FlyBase ID
FBal0240756
Feature type
allele
Associated gene
Dmel\Snmp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    SnmpZ0429 contains a 5bp deletion that introduces a frame-shift and a concomitant premature termination at residue 204, approximately half-way through the protein.

    (Jin et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:21,166,997..21,167,001 [-]
    Comment:

    5 bp deletion that causes a frameshift and early termination near the middle of the Snmp1 protein.

    (Jin et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In Snmp1Z0429 mutants, ai2 sensilla/Or83c neurons show delayed deactivation upon stimulation with farnesol, as compared to controls.

        (Scheuermann and Smith, 2019)

        Although they are still activated by farnesol, ai2a neurons from Snmp1Z0429 mutants have defective response kinetics.

        (Ronderos et al., 2014)

        SnmpZ0429 mutants are defective for cVA (11-cis-vaccenyl acetate) sensitivity. T1 neurons from SnmpZ0429 mutants display increased basal activity (14-25 spikes per second compared with wild-type at ~1 spike per second). Basal activity and olfactory responses of basiconic neurons in SnmpZ0429 mutants are indistinguishable from wild-type controls.

        (Jin et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        Snmp1Z0429 has abnormal neurophysiology | adult stage phenotype, enhanceable by Df(3R)OS-EF-

        (Scheuermann and Smith, 2019)
        Suppressed by
        NOT suppressed by
        Statement
        Reference

        Snmp1Z0429 has abnormal smell perception phenotype, non-suppressible by lush1

        (Jin et al., 2008)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        In Snmp1Z0429, Df(3R)OS-EF- double mutants, ai2 sensilla/Or83c neurons show a delayed deactivation upon stimulation with farnesol that is more severe than that of Snmp1Z0429 single mutants and similar to that of Df(3R)OS-EF- single mutants.

        (Scheuermann and Smith, 2019)

        Driving Or83cScer\UAS.cRa with Scer\GAL4Snmp1.PR restores farnesol sensitivity to ai2b neurons in Snmp1Z0429 mutants.

        (Ronderos et al., 2014)

        Double mutants defective for lush1 SnmpZ0429 exhibit high spontaneous activity, indicating that Snmp functions downstream of lush in cVA signaling.

        (Jin et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Snmp1Z0429 is rescued by Snmp1Or67d.PJ

        (Jin et al., 2008)
        Not rescued by

        Snmp1Z0429 is not rescued by Snmp1lush.PJ

        (Jin et al., 2008)
        Comments

        Expression of SnmpOr67d.PJ in T1 neurons restores cVA sensitivity in SnmpZ0429 mutants.

        Expression of Snmplush.PJ in support cells fails to restore cVA sensitivity in SnmpZ0429 mutants.

        (Jin et al., 2008)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Snmp1Z0429
        (Scheuermann and Smith, 2019, Ha et al., 2014, Ronderos et al., 2014)
        SnmpZ0429
        (Jin et al., 2008)
        vainsD1
        (Jin et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)