FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\atlR214C.UAS
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General Information
Symbol
Dmel\atlR214C.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241129
Feature type
allele
Associated gene
Dmel\atl
Associated Insertion(s)
Carried in Construct
P{UAS-atl.R214C}
Key Links
Transgenic product class
missense_variant
(Lee et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lee et al., 2008)
Mutagen
in vitro construct
(Lee et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-atl.R214C}
Cytology
Description

Amino acid replacement: R214C.

(Lee et al., 2008)

UAS regulatory sequences drive expression of a mutant form of atl.

(Lee et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
atl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia 3A
      CEA
      (Lee et al., 2008)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing atlR214C.Scer\UAS under the control of Scer\GAL4ple.PF show a reduced ability to climb after vortexing compared to controls. In addition, the number of dopaminergic neurons is reduced in these flies at 15 days after eclosion.

      (Lee et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      atlR214C.UAS/Scer\GAL4ple.PF partially rescues atl1

      (Lee et al., 2008)

      atlR214C.UAS/Scer\GAL4DAT.PL partially rescues atl1

      (Lee et al., 2008)
      Comments

      Expression of atlR214C.Scer\UAS under the control of either Scer\GAL4ple.PF or Scer\GAL4DAT.PL partially rescues the ability of atl1 flies to climb after vortexing.

      (Lee et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      atlR214C.Scer\UAS
      atlR214C.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)