FB2026_02 , released June 18, 2026
Allele: Dmel\Orc6Orc6.UAS.GFP
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General Information
Symbol
Dmel\Orc6Orc6.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0241168
Feature type
allele
Associated gene
Dmel\Orc6
Associated Insertion(s)
Carried in Construct
P{Orc6-UAS-Orc6.N-GFP}
Also Known As
GFP-orc6-wt
Key Links
Transgenic product class
wild_type
(Balasov et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Balasov et al., 2009)
Mutagen
in vitro construct
(Balasov et al., 2009)
Progenitor genotype
Carried in construct
P{Orc6-UAS-Orc6.N-GFP}
Cytology
Description

The native Orc6 promoter and UAS regulatory sequences are fused upstream of the full-length wild-type Orc6 coding sequence, which is tagged at the N-terminal end with GFP.

(Balasov et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
Orc6
UAS
Encoded product / tool
Orc6
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Meier-Gorlin syndrome 3
      modeled by Orc635
      (Balasov et al., 2020)
      modeled by Orc6::Hsap\ORC6HDK23E.Orc6.UAS.GFP
      (Balasov et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      FBal0241168:, Orc635 is partially rescued by Scer\GAL4αTub84B.PL, Orc6Orc6.UAS.GFP/Orc6Orc6.UAS.GFP

      (Balasov et al., 2020)

      FBal0241168:, Orc635 is partially rescued by Orc6Orc6.UAS.GFP/Orc6Orc6.UAS.GFP

      (Balasov et al., 2020)
      Rescues

      Orc6Orc6.UAS.GFP rescues Orc635

      (Balasov et al., 2009)
      Partially rescues

      Scer\GAL4αTub84B.PL, Orc6Orc6.UAS.GFP/Orc6Orc6.UAS.GFP partially rescues FBal0241168:, Orc635

      (Balasov et al., 2020)

      Orc6Orc6.UAS.GFP/Orc6Orc6.UAS.GFP partially rescues FBal0241168:, Orc635

      (Balasov et al., 2020)

      Orc6Orc6.UAS.GFP/Scer\GAL4Tub.PU partially rescues Orc635

      (Balasov et al., 2015)

      Orc6Orc6.UAS.GFP partially rescues Orc635

      (Balasov et al., 2015)
      Comments

      Expression of Orc6Orc6.Scer\UAS.T:Avic\GFP under the control of its native promoter or the Scer\GAL4tub.PU driver almost completely restores the viability of Orc635 mutants. The abnormal brain cell karyotype as well as the DNA replication defects observed in brain and testes of Orc635 third instar larvae are also rescued by Orc6Orc6.Scer\UAS.T:Avic\GFP expression from its native promoter.

      (Balasov et al., 2015)

      Expression of Orc6T:Avic\GFP results in the release of Orc635 mutant cells from G1 arrest, as shown by the ratio of cells containing either 1 or 2 centrosomes being indistinguishable from cells obtained from heterozygous siblings.

      (Balasov et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Orc6Orc6.Scer\UAS.T:Avic\GFP
      Orc6Orc6.UAS.GFP
      Orc6T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (4)