FlyBase Allele Report: Mmus\Chmp4b[UAS.cAa]

General Information

Symbol

Mmus\Chmp4b^UAS.cAa

Species

M. musculus

Name

FlyBase ID

FBal0241181

Feature type

allele

Associated gene

Mmus\Chmp4b

Associated Insertion(s)

Carried in Construct

P{UAS-sNF7-2.A}

Transgenic product class

wild_type

(Ahmad et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ahmad et al., 2009)

Mutagen

in vitro construct

(Ahmad et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-sNF7-2.A}

Cytology

Description

UAS regulatory sequences drive expression of Mmus\Chmp4b.

(Ahmad et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mmus\Chmp4b

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PF

(Ahmad et al., 2009)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Ahmad et al., 2009)

Detailed Description

Statement

Reference

Expression of Mmus\Chmp4b^Scer\UAS.cAa under the control of Scer\GAL4^GMR.PF results in a mild rough eye phenotype in 80% of cases.

(Ahmad et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Mmus\Chmp4b^UAS.cAa, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Ahmad et al., 2009)

Enhancer of

Statement

Reference

Mmus\Chmp4b^UAS.cAa, Scer\GAL4^GMR.PF is an enhancer of increased cell death phenotype of Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Ahmad et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mmus\Chmp4b^UAS.cAa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Ahmad et al., 2009)

Enhancer of

Statement

Reference

Mmus\Chmp4b^UAS.cAa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Ahmad et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Chmp4b with Hsap\CHMP2B^{Intron5.Scer\UAS} greatly enhances the severity of the rough eye phenotype compared to both single mutants (both under the control of Scer\GAL4^GMR.PF).

(Ahmad et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmus\Chmp4b^Scer\UAS.cAa

Mmus\Chmp4b^UAS.cAa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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