FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\capsC18fs
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General Information
Symbol
Dmel\capsC18fs
Species
D. melanogaster
Name
FlyBase ID
FBal0241213
Feature type
allele
Associated gene
Dmel\caps
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    7bp deletion, resulting in a frameshift after the 18th amino acid residue.

    (Shinza-Kameda et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Photoreceptor cell axon targeting in the medulla is highly disorganised in flies containing homozygous eyes (generated using the EGUF/hid method). The regular array of fascicles is disrupted and many axons cross over neighbouring bundles. Homozygous R8 axons often extend irregularly to abnormal positions, both in mosaic flies containing homozygous eyes generated using the EGUF/hid method and in flies containing small photoreceptor clones spanning less than two ommatidia. They may terminate at abnormal layers in the medulla, either terminating in the medulla at more superficial layers than the M3 layer (8%) or terminating between M3 and M6 (22%). They may also extend to and fasciculate with a neighbouring photoreceptor cell axon fascicle (23%).

        (Shinza-Kameda et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Suppressor of
        Statement
        Reference

        capsC18fs is a non-suppressor | somatic clone of axon & photoreceptor cell R7 | somatic clone phenotype of Nf-YC40

        (Morey et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mis-targeting of Nf-YC40 R7 neurons to the M3 layer of the medulla is not suppressed by capsC18fs.

        (Morey et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CapriciousC18fs
        (Kulkarni et al., 2016)
        capsC18fs
        (Shinza-Kameda et al., 2006)
        capsc18fs
        (Mummery-Widmer et al., 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)