FlyBase Allele Report: Dmel\Ltn1[G9156]

General Information

Symbol

Dmel\Ltn1^G9156

Species

D. melanogaster

Name

FlyBase ID

FBal0241256

Feature type

allele

Associated gene

Dmel\Ltn1

Associated Insertion(s)

P{EP}Ltn1^G9156

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bellen, 2010.1.28)

Progenitor genotype

Associated Insertion(s)

P{EP}Ltn1^G9156

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,552,164..19,552,164 [-]

(Khaket et al., 2024, Rimal et al., 2021, Li et al., 2020, Bellen, 2010.1.28)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{C99.UAS.Exel.Tag:MYC}

(Rimal et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ltn1^G9156, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

Ltn1^G9156, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-PR^PO-36.UAS

(Park et al., 2021)

Suppressor of

Statement

Reference

Ltn1^G9156, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Other

Statement

Reference

Ltn1^G9156, Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS has increased cell death | adult stage phenotype

(Park et al., 2021)

Ltn1^G9156, Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS has decreased size | adult stage phenotype

(Park et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ltn1^G9156, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

Ltn1^G9156, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-PR^PO-36.UAS

(Park et al., 2021)

Suppressor of

Statement

Reference

Ltn1^G9156, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of Zzzz\poly-GR^PO-36.UAS under the control of Scer\GAL4^GMR.PU induces a eye degeneration phenotype, which is enhanced by the co-expression of Ltn1^G9156, leading to a severely deformed eye and necrotic patches.

(Park et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30116

y¹ w^*; P{EP}Ltn1^G9156

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG32210^G9156

(Bellen, 2010.1.28)

Ltn1^EP

(Park et al., 2021)

Ltn1^G9156

(Park et al., 2021)

l(3)76BDr^G9156

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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