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General Information
Symbol
Hsap\NCAM1140.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0241458
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the Hsap\NCAM1-140 isoform.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\NCAM1140.Scer\UAS driven by Scer\GAL4Tab2-201Y does not affect pruning of mushroom body γ neurons.

Expression of Hsap\NCAM1140.Scer\UAS in a wild-type background, under the control of Scer\GAL4MS1075 causes minor ocellar sensory system axon guidance alterations in a few individuals.

Targeted expression of Hsap\NCAM1140.Scer\UAS under the control of Scer\GAL4Bx-MS1096 induces a number of axon guidance defects. Axons from the wing margin sensilla can also tangle and perforate the epithelial surface. At early stages of sensory axon extension, numerous ectopic contacts between axon and epithelium are seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Hsap\NCAM1140.UAS/Scer\GAL4MS1075 is a suppressor of abnormal neuroanatomy | temperature conditional phenotype of Nrgl3

Other
Phenotype Manifest In
Suppressor of
Statement
Reference

Hsap\NCAM1140.UAS/Scer\GAL4MS1075 is a suppressor of ocellar nerve | temperature conditional phenotype of Nrgl3

Hsap\NCAM1140.UAS/Scer\GAL4MS1075 is a suppressor of mechanosensory neuron | temperature conditional phenotype of Nrgl3

Other
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of bskDN.Scer\UAS.cUa with Hsap\NCAM1140.Scer\UAS driven by Scer\GAL4Tab2-201Y results in mushroom body γ lobe pruning defects.

Expression of Hsap\NCAM1140.Scer\UAS in a Nrgl3 background, under the control of Scer\GAL4MS1075 suppresses the Nrgl3 phenotype at the restrictive temperature, specifically OP axon alterations and BM axon guidance defects.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\NCAM1140.Scer\UAS
Hsap\NCAM1140.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)