FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\NCAM1140.UAS
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General Information
Symbol
Hsap\NCAM1140.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0241458
Feature type
allele
Associated gene
Hsap\NCAM1
Associated Insertion(s)
Carried in Construct
P{UAS-hNCAM.140}
Key Links
Transgenic product class
wild_type
(Kristiansen et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kristiansen et al., 2005)
Mutagen
in vitro construct
(Kristiansen et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-hNCAM.140}
Cytology
Description

UASt regulatory sequences drive expression of the Hsap\NCAM1-140 isoform.

(Kristiansen et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\NCAM1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\NCAM1140.Scer\UAS driven by Scer\GAL4Tab2-201Y does not affect pruning of mushroom body γ neurons.

      (Bornstein et al., 2015)

      Expression of Hsap\NCAM1140.Scer\UAS in a wild-type background, under the control of Scer\GAL4MS1075 causes minor ocellar sensory system axon guidance alterations in a few individuals.

      Targeted expression of Hsap\NCAM1140.Scer\UAS under the control of Scer\GAL4Bx-MS1096 induces a number of axon guidance defects. Axons from the wing margin sensilla can also tangle and perforate the epithelial surface. At early stages of sensory axon extension, numerous ectopic contacts between axon and epithelium are seen.

      (Kristiansen et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hsap\NCAM1140.UAS/Scer\GAL4MS1075 is a suppressor of abnormal neuroanatomy | temperature conditional phenotype of Nrgl3

      (Kristiansen et al., 2005)
      Other
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hsap\NCAM1140.UAS/Scer\GAL4MS1075 is a suppressor of ocellar nerve | temperature conditional phenotype of Nrgl3

      (Kristiansen et al., 2005)

      Hsap\NCAM1140.UAS/Scer\GAL4MS1075 is a suppressor of mechanosensory neuron | temperature conditional phenotype of Nrgl3

      (Kristiansen et al., 2005)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of bskDN.Scer\UAS.cUa with Hsap\NCAM1140.Scer\UAS driven by Scer\GAL4Tab2-201Y results in mushroom body γ lobe pruning defects.

      (Bornstein et al., 2015)

      Expression of Hsap\NCAM1140.Scer\UAS in a Nrgl3 background, under the control of Scer\GAL4MS1075 suppresses the Nrgl3 phenotype at the restrictive temperature, specifically OP axon alterations and BM axon guidance defects.

      (Kristiansen et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\NCAM1140.Scer\UAS
      Hsap\NCAM1140.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)