FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tlk27-9
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General Information
Symbol
Dmel\Tlk27-9
Species
D. melanogaster
Name
FlyBase ID
FBal0241543
Feature type
allele
Associated gene
Dmel\Tlk
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Li et al., 2009)
Progenitor genotype
Cytology
Description

imprecise excision of P{lacW}tlk27 generates a deletion between the 5'end of Rala and the 4th exon of tlk.

(Li et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Tlk27-9 has abnormal mitotic cell cycle | temperature conditional phenotype, enhanceable by marsEP2477

      (Li et al., 2009)
      Enhancer of
      Statement
      Reference

      tlk[+]/Tlk27-9 is an enhancer of viable | temperature conditional phenotype of marsEP2477

      (Li et al., 2009)

      tlk[+]/Tlk27-9 is an enhancer of abnormal mitotic cell cycle | temperature conditional phenotype of marsEP2477

      (Li et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The hatching rate from tlk27-9/+; marsEP2477 females is 48%, a further reduction from the 67% for marsEP2477 embryos, indicating that mars genetically interacts with tlk.

      The frequency of non-disjunction in male progenies from tlk27-9/+; marsEP2477 females at 28.5[o]C is 6.1%, much higher than those from marsEP2477 (1.1%) females. This increase in frequency of non-disjunction is also temperature dependent, since there is no substantial increases in progeny from tlk27-9/+; marsEP2477 females at 24[o]C when compared to marsEP2477 females.

      (Li et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tlk27-9
      (Liaw and Chiang, 2019)
      tlk27-9
      (Li et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)