FlyBase Allele Report: Dmel\PlexA[HM05221]

General Information

Symbol

Dmel\PlexA^HM05221

Species

D. melanogaster

Name

FlyBase ID

FBal0241712

Feature type

allele

Associated gene

Dmel\PlexA

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05221}

Also Known As

plexA RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05221}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05221

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult insulin secreting cell of pars intercerebralis, with Scer\GAL4^Ilp2.PR

(Clements et al., 2021)

adult insulin secreting cell of pars intercerebralis, with Scer\GAL4^repo.PL

(Clements et al., 2021)

axon | adult stage, with Scer\GAL4^elav.PLu

(Bustillo et al., 2024)

axon | adult stage, with Scer\GAL4^ey-OK107

(Bustillo et al., 2024)

egg, with Scer\GAL4^NP1624

(Stedden et al., 2019)

eye photoreceptor cell | adult stage, with Scer\GAL4^elav.PLu

(Bustillo et al., 2024)

follicle cell, with Scer\GAL4^NP1624

(Stedden et al., 2019)

lamina monopolar neuron L3 | P-stage, with PlexA^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Pecot et al., 2013)

medulla layer | adult stage, with Scer\GAL4^elav.PLu

(Bustillo et al., 2024)

medulla layer M6 | P-stage, with PlexA^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Pecot et al., 2013)

neurite | adult stage | ectopic, with Scer\GAL4^Ilp2.PR

(Clements et al., 2021)

neurite | adult stage | ectopic, with Scer\GAL4^repo.PL

(Clements et al., 2021)

photoreceptor cell R7 | adult stage, with Scer\GAL4^elav.PLu

(Bustillo et al., 2024)

photoreceptor cell R7 | adult stage, with Scer\GAL4^ey-OK107

(Bustillo et al., 2024)

stress fiber | oogenesis, with Scer\GAL4^NP1624

(Stedden et al., 2019)

Detailed Description

Statement

Reference

Eggs from females expressing PlexA^HM05221 under the control of Scer\GAL4^NP1624 (together with Dicer-2, for efficient RNAi) are rounder than from controls. There is no obvious follicular epithelium migration; stress fibers alignment decreases until stage 5 but then recovers through stage 7.

(Stedden et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

PlexA^HM05221, Scer\GAL4^NP1624 has abnormal size | oogenesis phenotype, enhanceable by Lar^bola2/Lar[+]

(Stedden et al., 2019)

PlexA^HM05221, Scer\GAL4^NP1624 has visible | oogenesis phenotype, enhanceable by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

PlexA^HM05221, Scer\GAL4^NP1624 has egg phenotype, enhanceable by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30483

y¹ sc^* v¹ sev²¹; P{TRiP.HM05221}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PlexA^HM05221

(Sasse and Klämbt, 2016)

plexA^HM05221

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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