FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4Foma1
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General Information
Symbol
Scer\GAL4Foma1
Species
S. cerevisiae
Name
FlyBase ID
FBal0241838
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GAL4}Foma1
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GAL4}Foma1
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GAL4}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        adult stage
        adult optic lobe neuron | subset
        (Katsov and Clandinin, 2008)
        alpha'/beta' Kenyon cell | subset
        (Katsov and Clandinin, 2008)
        lobula plate | restricted
        (Katsov and Clandinin, 2008)
        lamina monopolar neuron L2
        (Katsov and Clandinin, 2008)
        translobula plate neuron | subset
        (de Vries and Clandinin, 2012)
        lobula plate tangential neuron | subset
        (de Vries and Clandinin, 2012)
        lobula columnar neuron | subset
        (de Vries and Clandinin, 2012)
        adult mushroom body gamma-lobe | restricted
        (de Vries and Clandinin, 2012)
        Additional Information
        Statement
        Reference

        ScerGAL4Foma1 drives expression in a small cluster of optic lobe neurons that innervate the lobula complex and in the gamma lobe of the mushroom body. Five cells are labeled in the optic lobe, belonging to three distinc morphological types: one translobula plate neuron with processes in the lobula complex, one lobula columnar neuron which arborises in the proximal layers of the lobula and projects to the protocerebrum and three lobula plate tangential neurons with few processes in the lobula plate that project to the central brain.

        (de Vries and Clandinin, 2012)

        ScerGAL4Foma1 labels a cluster of three neurons per optic lobe which extend arbours into layers of the lobula-plate.

        (Katsov and Clandinin, 2008)
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with 590 nm (red) light) of Scer\GAL4Foma1 neurons in adults significantly increases takeoff rates, compared to controls; these are a range of long and short duration takeoffs; a subset of these flies also display seizure-like leg extensions, seizures, but not takeoffs occur in decapitated flies due to activation.

        (von Reyn et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Scer\GAL4Foma1
        Name Synonyms
        Failed optomotor assay-1
        (Katsov and Clandinin, 2008)
        Secondary FlyBase IDs
          References (3)