FB2026_03 , released September 17, 2026
Allele: Dmel\unc-104172
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General Information
Symbol
Dmel\unc-104172
Species
D. melanogaster
Name
FlyBase ID
FBal0241900
Feature type
allele
Associated gene
Dmel\unc-104
Associated Insertion(s)
Carried in Construct
Also Known As
imac172
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Pack-Chung et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: P12L.

(Pack-Chung et al., 2007)

FLPase activity in the eye using the 'EGUF-hid' method (FBrf0110880) generates a misense mutation within the predicted colied-coil domain of unc-104.

(Pack-Chung et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,763,263..16,763,263 [-]
Nucleotide change:

C16763263T

Amino acid change:

P12L | unc-104-PB; P12L | unc-104-PC; P12L | unc-104-PD; P12L | unc-104-PE; P12L | unc-104-PF; P12L | unc-104-PG; P12L | unc-104-PH; P12L | unc-104-PI

Reported amino acid change:

P12L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Pack-Chung et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc-104172 heterozygotes do not show ddaC neuron pruning defects at 16h after puparium formation, as compared to controls.

      (Zong et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      unc-104[+]/unc-104172 is an enhancer of abnormal neuroanatomy | pupal stage P5 phenotype of Df(3R)Exel7310/prd1M56

      (Zong et al., 2018)

      unc-104[+]/unc-104172 is an enhancer of abnormal size | pupal stage P5 phenotype of Df(3R)Exel7310/prd1M56

      (Zong et al., 2018)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      unc-104[+]/unc-104172 is an enhancer of dendritic tree | pupal stage P5 phenotype of Df(3R)Exel7310/prd1M56

      (Zong et al., 2018)

      unc-104[+]/unc-104172 is an enhancer of larval dorsal multidendritic neuron ddaC | pupal stage P5 phenotype of Df(3R)Exel7310/prd1M56

      (Zong et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for unc-104172 enhances the ddaC neuron pruning defects observed in prd1M56/Df(3R)Exel7310 transheterozygous at 16h after puparium formation, as the persisting dendrites become significantly longer.

      (Zong et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      imac172
      (Zong et al., 2018, Pack-Chung et al., 2007)
      unc-104172
      Name Synonyms
      Secondary FlyBase IDs
        References (2)