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General Information
Symbol
Dmel\tutlHL01565.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241905
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of tutl coding sequences corresponding to the HL01565 isoform.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pan-neuronal expression of the membrane-bound tutlHL01565.Scer\UAS isoform under the control of Scer\GAL4elav-C155 does not generate a phenotype.

Overexpression of tutlHL01565.Scer\UAS under the control of Scer\GAL4sca-109-68, Scer\GAL4how-24B or Scer\GAL4G14 produces branching of the ISNd nerve, stalling of motor nerves, with some nerves, such as the transverse nerve, innervating muscles that are not their normal targets.

Overexpression of tutlHL01565.Scer\UAS in a wild-type background using the retina-specific Scer\GAL4GMR.PF produces neuronal defects in that many retinal axons stall before reaching their targets and some sprout extra axonal processes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Post-mitotic neuronal expression of tutlHL01565.Scer\UAS under the control of either Scer\GAL4sim.PS or Scer\GAL4elav-C155 fully rescues the midline crossing defects found in tutlex383 and tutlex383/Df(2L)ed-dp mutants. Expression under the control of Scer\GAL4repo does not rescue the phenotype, indicating that expression near the midline is important for rescue.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
tutlHL01565.Scer\UAS
tutlHL01565.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)