FB2026_02 , released June 18, 2026
Allele: Dmel\CkIIβRNAi.fl.UAS
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General Information
Symbol
Dmel\CkIIβRNAi.fl.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241910
Feature type
allele
Associated gene
Dmel\CkIIβ
Associated Insertion(s)
Carried in Construct
P{UAS-CkIIβ.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Lear et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Lear et al., 2005)
Mutagen
in vitro construct
(Lear et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-CkIIβ.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of two copies of full-length CkIIβ sequences (corresponding to RE31047) ordered as inverted repeats separated by a w gene intron.

(Lear et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CkIIβ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing CkIIβdsRNA.fl.Scer\UAS under the control of Scer\GAL4P2.4.Pdf show dampened locomotor behavioral rhythms after being placed in constant darkness conditions.

      (Zhang et al., 2010)

      Expression of CkIIbetadsRNA.fl.Scer\UAS under the control of Scer\GAL4P2.4.Pdf lengthens DD behavoural period by approximately 6 hours.

      (Zhang et al., 2010)

      Targeted expression of CkIIβdsRNA.fl.Scer\UAS in the PDF neurons under the control of Scer\GAL4P2.4.Pdf results in a phase delay in circadian behavior on the first day of DD, consistent with period lengthening effects.

      (Lear et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      CkIIβRNAi.fl.UAS, Scer\GAL4P2.4.Pdf has abnormal circadian rhythm phenotype, suppressible by Pdfrsc29

      (Lear et al., 2005)
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4P2.4.Pdf/CkIIβRNAi.fl.UAS is a non-enhancer of abnormal circadian rhythm phenotype of Pdfrsc29

      (Lear et al., 2005)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4P2.4.Pdf/CkIIβRNAi.fl.UAS is a non-suppressor of abnormal circadian rhythm phenotype of Pdfrsc29

      (Lear et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant flies, where CkIIβdsRNA.fl.Scer\UAS is expressed in PDF neurons (under the control of Scer\GAL4P2.4.Pdf in a pdfrsc29 background display a behavioral phase comparable to that of pdfrsc29 mutants, i.e. early phase, but distinct from Scer\GAL4P2.4.Pdf; CkIIβdsRNA.fl.Scer\UAS phase delay phenotypes.

      (Lear et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CkIIβRNAi.fl.UAS
      CkIIβdsRNA.fl.Scer\UAS
      CkIIβdsRNA.fl.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)