FB2026_02 , released June 18, 2026
Allele: Dmel\Pdfrsc29
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General Information
Symbol
Dmel\Pdfrsc29
Species
D. melanogaster
Name
FlyBase ID
FBal0241908
Feature type
allele
Associated gene
Dmel\Pdfr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
transposable element activity
(Lear et al., 2005)
Progenitor genotype
Caused by aberration
In(1)sc29
Cytology
Description

Insertion of a 412 retrotransposon in an antisense orientation disrupts the sequence coding for the extracellular domain of pdfr.

(Lear et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In DD conditions, pdfrsc29 mutant flies display reduced rhythmicity. A day-by-day analysis reveals a dampening of rhythmicity upon release into constant darkness, with a reduced morning peak and an evening activity peak, clearly evident only on the first day of DD. pdfrsc29 mutants display a loss of morning anticipation as well as a phase advance of the evening activity peak in LD.

      The male progeny of out-crossed virgin pdfrsc29 mutant females retina LD and DD phenotypes, but heterozygous females are essentially wild-type.

      pdfrsc29 flies exhibit an evening activity peak phase comparable to or perhaps advanced in comparison to wild-type.

      (Lear et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant flies, where CkIIαScer\UAS.cLb is expressed in PDF neurons (under the control of Scer\GAL4P2.4.Pdf in a pdfrsc29 background display a beahvioral phase comparable to that of pdfrsc29 mutants, i.e. early phase, but distinct from Scer\GAL4P2.4.Pdf; CkIIαScer\UAS.cLb phase delay phenotypes.

      Double mutant flies, where CkIIβdsRNA.fl.Scer\UAS is expressed in PDF neurons (under the control of Scer\GAL4P2.4.Pdf in a pdfrsc29 background display a behavioral phase comparable to that of pdfrsc29 mutants, i.e. early phase, but distinct from Scer\GAL4P2.4.Pdf; CkIIβdsRNA.fl.Scer\UAS phase delay phenotypes.

      (Lear et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pdfrsc29
      gopsc29
      (Lear et al., 2005)
      pdfrsc29
      Name Synonyms
      Secondary FlyBase IDs
        References (1)