FB2026_02 , released June 18, 2026
Allele: Dmel\Mps1Exc23
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General Information
Symbol
Dmel\Mps1Exc23
Species
D. melanogaster
Name
FlyBase ID
FBal0241960
Feature type
allele
Associated gene
Dmel\Mps1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gilliland et al., 2007)
Progenitor genotype
Mps1GS13084
(Gilliland et al., 2007)
Cytology
Description

Imprecise excision of P{GSV6}aldGS13084 leaves 130 nucleotides from the 5' end of the P-element, inserted after the 14th nucleotide of the 5'UTR.

(Gilliland et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      aldExc23/Df(3R)AN6 mutants undergo premature separation in all oocytes.

      Cytological studies of aldC3/aldExc23 mutant oocytes reveals a high frequency of chromosomes that appear to have procociously entered anaphase I, and in which achiasmate homologs are often seen as still physically associated and thus perhaps 'trapped' on one side of the spindle. Visualisation of meiosis in aldC3/aldExc23 oocytes by live video microscopy reveals that shortly after spindle formation, the DNA fails to remain as a single mass at the metaphase plate, and soon enters an anaphase-like configuration where first the chromosomes and then the spindle appears to divide into two masses. This entry into anaphase takes less time than achiasmate homologs often require to achieve proper orientation, and is never observed during wild-type prometaphase.

      (Gilliland et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mps1Exc23
      aldExc23
      (Gilliland et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)