FlyBase Allele Report: Dmel\mts[JF02805]

General Information

Symbol

Dmel\mts^JF02805

Species

D. melanogaster

Name

FlyBase ID

FBal0242385

Feature type

allele

Associated gene

Dmel\mts

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02805}

Also Known As

mts RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02805}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02805

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease 8

modeled by Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Sim et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

(Sakuma et al., 2016)

lethal - all die before end of larval stage, with Scer\GAL4^da.G32

(Nandi et al., 2022)

visible, with Scer\GAL4^bbg-C96

(Kwon et al., 2013)

Phenotype Manifest In

NMJ bouton | increased number, with Scer\GAL4^RapGAP1-OK6

(Sakuma et al., 2016)

NMJ bouton | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

wing margin, with Scer\GAL4^bbg-C96

(Kwon et al., 2013)

Detailed Description

Statement

Reference

Expression of mts^JF02805 under the control of Scer\GAL4^RapGAP1-OK6 results in a significant increase in the number of satellite boutons on neuromuscular junctions in third instar larval muscles.

(Sakuma et al., 2016)

Expression of mts^JF02805 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

Expression of mts^JF02805 in the fat body under the control of Scer\GAL4^DcG has no effect on trehalose levels compared with controls.

(Ugrankar et al., 2015)

Expression of mts^JF02805 under the control of Scer\GAL4^bbg-C96 results in a high penetrance of wing nicking.

(Kwon et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mts^JF02805, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Acn^UAS.cNa, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Scer\GAL4^bbg-C96/mts^JF02805 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

NOT Enhancer of

Statement

Reference

Scer\GAL4^RapGAP1-OK6/mts^JF02805 is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^RapGAP1-OK6, Strip^RNAi.UAS.9

(Sakuma et al., 2016)

Other

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF, mts^JF02805 has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Phenotype Manifest In

Enhancer of

Statement

Reference

mts^JF02805, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Acn^UAS.cNa, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Scer\GAL4^bbg-C96/mts^JF02805 is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

NOT Enhancer of

Statement

Reference

Scer\GAL4^RapGAP1-OK6/mts^JF02805 is a non-enhancer of NMJ bouton | increased number phenotype of Scer\GAL4^RapGAP1-OK6, Strip^RNAi.UAS.9

(Sakuma et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of mts^JF02805 enhances the rough rough eye phenotype induced by the expression of Acn^UAS.cNa under the control of Scer\GAL4^GMR.PF, and leads to a small eye.

(Nandi et al., 2022)

The increased number of satellite boutons on neuromuscular junctions in third instar larvae expressing Strip^{dsRNA.shRNA.Scer\UAS.9} under the control of Scer\GAL4^RapGAP1-OK6 is not further enhanced by co-expression of mts^JF02805.

(Sakuma et al., 2016)

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also co-expressing mts^JF02805.

(Kwon et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27723

y¹ v¹; P{TRiP.JF02805}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mts^JF02805

(Neisch et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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