FlyBase Allele Report: Dmel\Acn[UAS.cNa]

General Information

Symbol

Dmel\Acn^UAS.cNa

Species

D. melanogaster

Name

FlyBase ID

FBal0301140

Feature type

allele

Associated gene

Dmel\Acn

Associated Insertion(s)

Carried in Construct

P{UAS-Acn.WT}

Also Known As

UAS-Acn^wt

Key Links

Transgenic product class

wild_type

(Nandi et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Nandi et al., 2014)

Mutagen

in vitro construct

(Nandi et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-Acn.WT}

Cytology

Description

UAS regulatory sequences drive expression of wild-type Acn coding sequences.

(Nandi et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Acn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^Bx-MS1096

(Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PF

(Nandi et al., 2022, Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^nub-AC-62

(Tyra et al., 2020)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Nandi et al., 2022, Tyra et al., 2020, Nandi et al., 2014)

eye | heat sensitive, with Scer\GAL4^GMR.PF

(Nandi et al., 2014)

wing, with Scer\GAL4^Bx-MS1096

(Tyra et al., 2020)

wing, with Scer\GAL4^nub-AC-62

(Tyra et al., 2020)

wing posterior compartment, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

Detailed Description

Statement

Reference

The expression of Acn^UAS.cNa under the control of Scer\GAL4^GMR.PF induces a rough eye phenotype.

(Nandi et al., 2022)

Expression of Acn^Scer\UAS.cNa under the control of Scer\GAL4^GMR.PF results in a mildly rough eye. This phenotype is enhanced by an elevated temperature (28[o]C).

(Nandi et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by PpD6^HMC05322, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Pp1-13C^HMS00465, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Nil^HMC06011, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by PpV^GL00398, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by CG15035^HMJ22662, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by flw^HMS04465, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by mts^JF02805, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

NOT Enhanced by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-enhanceable by Pp1α-96A^HMS02154, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Suppressed by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Pp1-Y1^HMJ22013, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Pp2B-14D^JF01949, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by PpV^HMC04959, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by PpY-55A^HMC04834, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Nil^WT.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Df(2R)ED3728

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Df(2L)al

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Df(3R)ED6187

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Df(3R)ED5664

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by hpo^JF02740, Scer\GAL4^GMR.PF

(Tyra et al., 2020)

NOT suppressed by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by Pp1α-96A^HMS02154, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Suppressor of

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of increased size | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S74.S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of increased size | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S74.S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of increased mortality during development phenotype of Scer\GAL4^GMR.PF, yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Tyra et al., 2020)

Other

Statement

Reference

Acn^UAS.cNa, CG15035^HMJ22662, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF, flw^HMS04465 has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Acn^UAS.cNa, Pp1-13C^HMS00465, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Acn^UAS.cNa, Nil^HMC06011, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF, mts^JF02805 has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Acn^UAS.cNa, PpD6^HMC05322, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF, yki^{S168A.UAS.EGFP,Tag:HA} has visible | adult stage phenotype

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF, yki^{S168A.UAS.EGFP,Tag:HA} has decreased size | adult stage phenotype

(Tyra et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by PpD6^HMC05322, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Pp1-13C^HMS00465, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Nil^HMC06011, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by PpV^GL00398, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CG15035^HMJ22662, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by flw^HMS04465, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by mts^JF02805, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Akt^UAS.Exel, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Dcp-1^GD10729, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

NOT Enhanced by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Pp1α-96A^HMS02154, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Dredd^KK110428, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Dronc^GD12376, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Suppressed by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Pp1-Y1^HMJ22013, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Pp2B-14D^JF01949, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by PpV^HMC04959, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by PpY-55A^HMC04834, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Nil^WT.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(2R)ED3728

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(2L)al

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(3R)ED6187

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(3R)ED5664

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by hpo^JF02740, Scer\GAL4^GMR.PF

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Atg7^GD11671, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Atg1^GD7149, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

NOT suppressed by

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Pp1α-96A^HMS02154, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Suppressor of

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, yki^{S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Acn^UAS.cNa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, yki^{S74.S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Other

Statement

Reference

Acn^UAS.cNa, Scer\GAL4^GMR.PF, yki^{S168A.UAS.EGFP,Tag:HA} has eye phenotype

(Tyra et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of flw^HMS04465, CG15035^HMJ22662, mts^JF02805, Nil^HMC06011, PpD6^HMC05322 or Pp1-13C^HMS00465 enhances the rough rough eye phenotype induced by the expression of Acn^UAS.cNa under the control of Scer\GAL4^GMR.PF, and leads to a small eye.

(Nandi et al., 2022)

Scer\GAL4^GMR.PF-driven expression of Akt1^{Scer\UAS.Exel} enhances the rough eye phenotype of the Acn^Scer\UAS.cNa transgene.

Expression of Dcp-1^GD10729 enhances the rough eye phenotype and reduces the overall eye size in flies expressing Acn^Scer\UAS.cNa under the control of Scer\GAL4^GMR.PF.

Expression of Dredd^KK110428 in the developing eye does not affect the eye roughness seen upon expression of Acn^Scer\UAS.cNa under the control of Scer\GAL4^GMR.PF.

Expression of Dronc^GD12376 in the developing eye does not affect the eye roughness seen upon expression of Acn^Scer\UAS.cNa under the control of Scer\GAL4^GMR.PF.

Knockdown of Atg1 through expression of Atg1^GD7149 under the control of Scer\GAL4^GMR.PF suppresses the Acn^Scer\UAS.cNa-induced rough eye phenotype.

Knockdown of Atg7 through expression of Atg7^GD11671 under the control of Scer\GAL4^GMR.PF suppresses the Acn^Scer\UAS.cNa-induced rough eye phenotype.

(Nandi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Acn^Scer\UAS.cNa

Acn^UAS.cNa

Name Synonyms

Secondary FlyBase IDs

References (4)

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