FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\OteEMS
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General Information
Symbol
Dmel\OteEMS
Species
D. melanogaster
Name
FlyBase ID
FBal0242605
Feature type
allele
Associated gene
Dmel\Ote
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jiang et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: ??term.

(Barton et al., 2013)

8bp deletion in the coding sequence (residues 227-234).

(Jiang et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:18,276,846..18,276,853 [-]
Comment:

Inferred locaiton of 8bp deletion that is reported to remove bases 227-234 of the Ote coding sequence.

(Jiang et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ovaries from homozygous, OteEMS/OtePK and OteB279/OteEMS females have a range of mutant germarial phenotypes. These include germaria containing no germ cells, germaria containing fusomes only, germaria containing both spectrosomes and fusomes (the vast majority of this class carry a single developing cyst connected by an incompletely branched fusome) and germaria containing spectrosomes only (germaria in this class contain a higher number of spectrosome containing cells than normal). The "empty germaria" and "spectrosomes only" classes are recovered at high frequency.

      (Barton et al., 2013)

      Homozygous females have small ovaries. 60-70% of germaria in the ovaries of newly eclosed homozygous females are either empty or contain only a few differentiated germ cells attached to one or two abnormal egg chambers. The remaining 30-40% of germaria each have one or two germline stem cells carrying anterior-positioned spectrosomes, but are mostly composed of sickly, undifferentiated germ cells and differentiated cysts (indicating an abnormal germ cell lineage).

      Homozygous germline stem cell clones are lost more quickly from ovaries compared to control clones.

      (Jiang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      OteB279

      (Jiang et al., 2008)
      Rescued by

      OteEMS is rescued by Ote+t5.9

      (Jiang et al., 2008)

      OteEMS is rescued by Scer\GAL4VP16.nanos.UTR/OteUASp.cJa

      (Jiang et al., 2008)
      Not rescued by

      OteEMS is not rescued by OteUASp.cJa/Scer\GAL4αTub84B.PL

      (Jiang et al., 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EMS1146
      (Jiang et al., 2008)
      OteEMS
      oteEMS
      (Barton et al., 2013, Jiang et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)