FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hecas.UAS.Tag:FLAG
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General Information
Symbol
Dmel\hecas.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0242668
Feature type
allele
Associated gene
Dmel\heca
Associated Insertion(s)
Carried in Construct
P{UAS-heca.s.FLAG}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Steneberg and Samakovlis, 2001)
Progenitor genotype
Carried in construct
P{UAS-heca.s.FLAG}
Cytology
Description

UASt regulatory sequences drive expression of a form of hdc in which sequences immediately downstream of the internal UAA stop codon have been deleted. The hdc sequences are tagged with Tag:FLAG.

(Steneberg and Samakovlis, 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
heca
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hdcs.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4btl.PS results in a reduction of terminal branches in the tracheal system in embryos (the average length of the terminal branches is decreased by 32%).

      (Steneberg and Samakovlis, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      hecas.UAS.Tag:FLAG/Scer\GAL4ppk.1.9 partially rescues heca43

      (Loncle and Williams, 2012)
      Comments

      Expression of hdcs.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4ppk.1.9 partially rescues the defects in dendrite severing which are seen in the ddaC neurons of hdc43 homozygous pupae.

      (Loncle and Williams, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hdcs.Scer\UAS.T:Zzzz\FLAG
      hdcs.UAS.Tag:FLAG
      hecas.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)