FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MED626
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General Information
Symbol
Dmel\MED626
Species
D. melanogaster
Name
FlyBase ID
FBal0242671
Feature type
allele
Associated gene
Dmel\MED6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Gim et al., 2001)
Mutagen
ethyl methanesulfonate
(Gim et al., 2001)
Progenitor genotype
Cytology
Description

G to A change (coordinate 60947 of GenBank accession AE003648), which disrupts the 3' splicing acceptor site of the second intron.

(Gim et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,766,894..9,766,894 [-]
Nucleotide change:

G9766894A

Comment:

G to A change which disrupts the 3' splice acceptor site.

(Gim et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes reach the third instar larval stage at 2 days after hatching (as do wild-type controls). However, they show a slower growth rate than normal and most die without pupating. A small number of the mutant larvae survive for several days but never develop into pupae.

      Mutant second instar larvae have small wing discs with an abnormal shape.

      Females containing homozygous germline clones are sterile.

      Homozygous somatic clones in the follicle cells are detected up to the two-cell stage, but when examined several days after clone induction, the homozygous clones have disappeared (leaving only the wild-type twin spot).

      Homozygous somatic clones are not recovered in the eye or imaginal discs.

      (Gim et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      MED626 is rescued by MED6+t10.4

      (Gim et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BE026
      (Gim et al., 2001)
      MED626
      dMed626
      (Gim et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)