FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snzC32
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General Information
Symbol
Dmel\snzC32
Species
D. melanogaster
Name
FlyBase ID
FBal0243027
Feature type
allele
Associated gene
Dmel\snz
Associated Insertion(s)
P{GawB}snzC32
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Suh et al., 2008)
Progenitor genotype
Associated Insertion(s)
P{GawB}snzC32
Cytology
Description

A P{GawB} insertion in the 5' UTR of snz.

(Suh et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      snzC32 hemizygous males and snzC32 homozygous females live longer than wild-type controls. Mortality analysis indicates that the primary effect of the snzC32 mutation is a reduction of initial mortality rate.

      snz5-SZ-4089/snzC32 and snzGG01409/snzC32 transheterozygotes live substantially longer than controls.

      Very old snzGG01409/snzC32 females remain fertile and produce viable offspring.

      The eggs produced by 6.5 week old controls show substantially reduced viability, while snzC32 homozygous females produce eggs that are resistant to this aging-related decline. Additionally, 9-week old snzC32 mutants produce approximately four times more progeny than 6.5-week controls.

      (Suh et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      snzC32 is rescued by Scer\GAL4snz-C32/snzUAS.cSa

      (Suh et al., 2008)
      Not rescued by

      snzC32 is not rescued by Scer\GAL4DcG/snzUAS.cSa

      (Suh et al., 2008)
      Comments

      Scer\GAL4snz-C32-driven snzScer\UAS.cSa rescues the lifespan extension phenotype of hemizygous snzC32 males.

      (Suh et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      snzC32
      Name Synonyms
      Secondary FlyBase IDs
        References (1)