FB2021_02, released April 13, 2021

Allele: Dmel\LamUAS.cMAa

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General Information
Symbol
Dmel\LamUAS.cMAa
Species
D. melanogaster
Name
FlyBase ID
FBal0243197
Feature type
allele
Associated gene
Dmel\Lam
Associated Insertion(s)
Carried in Construct
P{UAS-Lam.MA}
Also Known As
UAS-Lam
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Muñoz-Alarcón et al., 2007)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-Lam.MA}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of Lam coding sequences corresponding to the full-length cDNA clone LD38055.

      (Muñoz-Alarcón et al., 2007)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      Lam
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of LamScer\UAS.cMAa in 50 day-old flies under the control of Scer\GAL4Cg.PA results in a reduction in intestinal hyperplasia compared to controls.

      (Chen et al., 2014)

      Expression of LamScer\UAS.cMAa under the control of Scer\GAL4da.G32 at 25[o]C or 29[o]C results in lethality. Expression of the specific insertion P{UAS-Lam.MA}354 under the control of Scer\GAL4arm.PS is lethal at 29[o]C and viable at 25[o]C.

      (Muñoz-Alarcón et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      LamUAS.cMAa partially rescues LamK2/LamD395

      (Chen et al., 2014)
      Comments

      Expression of LamScer\UAS.cMAa in the fat body under the control of Scer\GAL4Cg.PA significantly rescues the intestinal hyperplasia seen in LamD395/LamK2 mutant flies. The eclosion rate is increased from ~8% to ~40%.

      (Chen et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LamScer\UAS.cMAa
      LamUAS.cMAa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)