FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CblK26
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General Information
Symbol
Dmel\CblK26
Species
D. melanogaster
Name
FlyBase ID
FBal0243201
Feature type
allele
Associated gene
Dmel\Cbl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wang et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q60term.

(Wang et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,425,486..8,425,486 [+]
Nucleotide change:

C8425486T

Amino acid change:

Q60term | Cbl-PA; Q60term | Cbl-PB

Reported amino acid change:

Q60term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wang et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CblK26 mutant eye mosaics display rough eyes and are larger compared to wild-type. They appear overgrown and exhibit larger ommatidia. This overgrown phenotype is visible in eye-antennal imaginal discs from the 3rd instar onwards.

      CblK26 mutants block apoptosis and cause over-recruitment of all cell types in the eye. CblK26 mutant ommatidium contains on average 11.44 R cells compared to eight in wild-type ommatidia and about three primary pigment cells instead of two in wild-type. The total numbers of secondary and tertiary pigment cells has increased from nine in wild-type to an average of fourteen per CblK26 ommatidium. CblK26 mutants exhibit 4.5 R7 cells per mutant ommatidium compared to one cell in wild-type.

      (Wang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      CblK26 is a suppressor of eye phenotype of EgfrDN.UAS, Scer\GAL4GMR.PF

      (Wang et al., 2008)

      CblK26 is a suppressor of eye phenotype of Ras85DN17.sev

      (Wang et al., 2008)

      CblK26 is a suppressor of eye | somatic clone phenotype of hidGMR.PG

      (Wang et al., 2008)

      CblK26 is a suppressor of photoreceptor cell R7 phenotype of sev14

      (Wang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The average number of total R cells in sev14, CblK26 mutant ommatidia is 11.12, containing more than four R7 cells per ommatidium.

      The small eye phenotype of WGMR.PG eye clones is suppressed by a homozygous CblK26 background.

      A CblK26 heterozygous background rescues the rough eye phenotype found in mutants expressing EgfrDN.Scer\UAS under the control of Scer\GAL4GMR.PF.

      A CblK26 heterozygous background moderately strongly suppresses the rough eye phenotype found in Ras85DN17.sev mutants.

      A CblK26 heterozygous background rescues the rough eye phenotype found in aopACT.sev mutants.

      (Wang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CblK26
      (Wang et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)