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General Information
Symbol
Dmel\CblK26
Species
D. melanogaster
Name
FlyBase ID
FBal0243201
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C8425486T

Amino acid change:

Q60term | Cbl-PA; Q60term | Cbl-PB

Reported amino acid change:

Q60term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q60term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

CblK26 mutant eye mosaics display rough eyes and are larger compared to wild-type. They appear overgrown and exhibit larger ommatidia. This overgrown phenotype is visible in eye-antennal imaginal discs from the 3rd instar onwards.

CblK26 mutants block apoptosis and cause over-recruitment of all cell types in the eye. CblK26 mutant ommatidium contains on average 11.44 R cells compared to eight in wild-type ommatidia and about three primary pigment cells instead of two in wild-type. The total numbers of secondary and tertiary pigment cells has increased from nine in wild-type to an average of fourteen per CblK26 ommatidium. CblK26 mutants exhibit 4.5 R7 cells per mutant ommatidium compared to one cell in wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

CblK26 has photoreceptor cell R7 phenotype, non-suppressible by CblK26

Suppressor of
Statement
Reference

CblK26 is a suppressor of eye | somatic clone phenotype of hidGMR.PG/WGMR.PG

CblK26 is a suppressor of eye phenotype of Ras85DN17.sev

CblK26 is a suppressor of photoreceptor cell R7 phenotype of sev14

NOT Suppressor of
Statement
Reference

CblK26 is a non-suppressor of photoreceptor cell R7 phenotype of CblK26

Additional Comments
Genetic Interactions
Statement
Reference

The average number of total R cells in sev14, CblK26 mutant ommatidia is 11.12, containing more than four R7 cells per ommatidium.

The small eye phenotype of WGMR.PG eye clones is suppressed by a homozygous CblK26 background.

A CblK26 heterozygous background rescues the rough eye phenotype found in mutants expressing EgfrDN.Scer\UAS under the control of Scer\GAL4GMR.PF.

A CblK26 heterozygous background moderately strongly suppresses the rough eye phenotype found in Ras85DN17.sev mutants.

A CblK26 heterozygous background rescues the rough eye phenotype found in aopACT.sev mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)