FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BsgUAS.cBa
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General Information
Symbol
Dmel\BsgUAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0243209
Feature type
allele
Associated gene
Dmel\Bsg
Associated Insertion(s)
Carried in Construct
P{UAS-Bsg.B}
Key Links
Transgenic product class
wild_type
(Besse et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Besse et al., 2007)
Mutagen
in vitro construct
(Besse et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Bsg.B}
Cytology
Description

UAS regulatory sequences drive expression of full-length Bsg coding sequences.

(Besse et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Bsg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Tub.PU/BsgUAS.cBa rescues Df(2L)Exel7034/Bsgk13638

      (Besse et al., 2007)

      Scer\GAL4Tub.PU/BsgUAS.cBa rescues Df(2L)Exel7034/Bsgk14308

      (Besse et al., 2007)

      Scer\GAL4Tub.PU/BsgUAS.cBa rescues BsgNP3198/Df(2L)Exel7034

      (Besse et al., 2007)

      Scer\GAL4elav-C155/BsgUAS.cBa rescues BsgNP3198/Df(2L)Exel7034

      (Besse et al., 2007)
      Fails to rescue

      Scer\GAL4Mhc.PW/BsgUAS.cBa fails to rescue BsgNP3198/Df(2L)Exel7034

      (Besse et al., 2007)

      Scer\GAL4how-24B/BsgUAS.cBa fails to rescue BsgNP3198/Df(2L)Exel7034

      (Besse et al., 2007)
      Comments

      Bsgk13638/Df(2L)Exel7034 transheterozygote lethality is rescued through expression of BsgScer\UAS.cBa under the control of Scer\GAL4tub.

      Bsgk14308/Df(2L)Exel7034 transheterozygote lethality is rescued through expression of BsgScer\UAS.cBa under the control of Scer\GAL4tub.

      BsgNP3198/Df(2L)Exel7034 transheterozygote lethality is rescued through expression of BsgScer\UAS.cBa under the control of Scer\GAL4tub.

      Presynaptic expression of BsgScer\UAS.cBa (under the control of Scer\GAL4elav-C155 in a BsgNP6293/Df(2L)Exel7034 mutant background rescues both the asynchronous evoked release and the high frequency of spontaneous release. Presynaptic expression decreases the amplitude of eEJCs and the frequency of single vesicle release below control levels, indicating a dose-dependent role. Expression post-synaptically, under the control of Scer\GAL4Mhc.PW does not rescue.

      Expression of wild-type BsgScer\UAS.cBa solely in muscles (using Scer\GAL4Mhc.PW or Scer\GAL4how-24B) or in neurons (using Scer\GAL4elav-C155) partially, but significantly, rescued both the increase in bouton size and the reduction of bouton number observed in BsgNP6293/Df(2L)Exel7034 mutant larvae. Near-complete rescue of bouton size and junction growth is obtained upon expression of BsgScer\UAS.cBa both pre- and postsynaptically (using Scer\GAL4Mhc.PW or Scer\GAL4how-24B post-synaptically and Scer\GAL4elav-C155 pre-synaptically).

      (Besse et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BsgScer\UAS.cBa
      BsgUAS.cBa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)