FlyBase Allele Report: Dmel\prtp[Δ1]

General Information

Symbol

Dmel\prtp^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0243430

Feature type

allele

Associated gene

Dmel\prtp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Kuraishi et al., 2009)

Progenitor genotype

P{GT1}prtp^BG00450

(Kuraishi et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion of sequences from -45 to +354 relative to the prtp transcription start site.

(Kuraishi et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,716,923..11,717,322 [+]

Comment:

Deletion resulting from the imprecise excision of P{GT1}prtp^BG00450 that extends from -45 to +354 relative to the prtp transcription start site. The start of prtp-RA was used as the transcription start site for the mapping.

(Kuraishi et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 2

modeled by park²⁵

(Silvera et al., 2025)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | larval stage

(Silvera and Ferreiro, 2024)

viable

(Kuraishi et al., 2009)

Phenotype Manifest In

embryonic/larval hemocyte

(Kuraishi et al., 2009)

embryonic/larval salivary gland | larval stage

(Silvera and Ferreiro, 2024)

larval glial cell

(Kuraishi et al., 2009)

nucleus | larval stage

(Silvera and Ferreiro, 2024)

Detailed Description

Statement

Reference

The level of phagocytosis is lower in prtp^Δ1 embryos than the control.

(Okada et al., 2012)

The distribution and population size of hemocytes is normal in mutant embryos. However, the level of phagocytosis occurring in hemocytes of mutant embryos is almost half that of control hemocytes.

repo-positive glial cells show a reduced level of phagocytosis in mutant embryos compared to wild-type embryos.

(Kuraishi et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

prtp^Δ1 has phenotype, non-enhanceable by CaBP1^Δ1

(Okada et al., 2012)

NOT suppressed by

Statement

Reference

prtp^Δ1 has phenotype, non-suppressible by CaBP1^Δ1

(Okada et al., 2012)

NOT Enhancer of

Statement

Reference

prtp^Δ1 is a non-enhancer of phenotype of CaBP1^Δ1

(Okada et al., 2012)

NOT Suppressor of

Statement

Reference

prtp^Δ1 is a non-suppressor of phenotype of CaBP1^Δ1

(Okada et al., 2012)

Other

Statement

Reference

drpr^Δ5/drpr[+], prtp^Δ1 has embryonic/larval hemocyte phenotype

(Kuraishi et al., 2009)

ced-6^J26/ced-6[+], prtp^Δ1 has embryonic/larval hemocyte phenotype

(Kuraishi et al., 2009)

Rac1^J11/Rac1[+], Rac2^Δ/Rac2[+], prtp^Δ1 has embryonic/larval hemocyte phenotype

(Kuraishi et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The level of phagocytosis in CaBP1^Δ1, prtp^Δ1 double mutant embryos is comparable to that in either single mutant.

(Okada et al., 2012)

The level of phagocytosis occurring in the hemocytes of prtp^Δ1 drpr^Δ5 or prtp^Δ1 ced-6^J26 double homozygous embryos is not significantly different from the reduction seen in each single homozygote.

prtp^Δ1/+ ; drpr^Δ5/+ and prtp^Δ1/+ ; ced-6^J26/+ double heterozygotes show a reduced level of phagocytosis in embryonic hemocytes (none of the single heterozygotes shows a reduction in phagocytosis compared to wild type).

prtp^Δ1/+ ; mbc^C1/+ double heterozygotes show a comparable level of phagocytosis in embryonic hemocytes as in wild-type controls.

prtp^Δ1/+ ; Rac1^J11 Rac2^Δ/+ triple heterozygotes show a reduced level of phagocytosis in embryonic hemocytes (neither prtp^Δ1/+ single heterozygotes nor Rac1^J11 Rac2^Δ/+ double heterozygotes show a reduction in phagocytosis compared to wild type).

(Kuraishi et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

prtp^Δ1 is rescued by prtp^UAS.cKa/Scer\GAL4^da.G32

(Kuraishi et al., 2009)

Not rescued by

prtp^Δ1 is not rescued by prtp^UAS.cKa/Scer\GAL4^srp.Hemo

(Kuraishi et al., 2009)

Comments

Expression of prtp^Scer\UAS.cKa under the control of Scer\GAL4^da.G32 completely rescues the defective phagocytosis phenotype seen in prtp^Δ1 hemocytes.

Expression of prtp^Scer\UAS.cKa under the control of Scer\GAL4^srp.Hemo does not rescue the defective phagocytosis phenotype seen in prtp^Δ1 hemocytes.

(Kuraishi et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Prtp^Δ1

(Nakano et al., 2019)

prtp^Δ1

(Silvera et al., 2025, Silvera and Ferreiro, 2024, Okada et al., 2012, Kuraishi et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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