FlyBase Allele Report: Dmel\Spc105R[P01511LE]

General Information

Symbol

Dmel\Spc105R^P01511LE

Species

D. melanogaster

Name

FlyBase ID

FBal0243492

Feature type

allele

Associated gene

Dmel\Spc105R

Associated Insertion(s)

P{PTT-un}Spc105R^P01511LE

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Schittenhelm et al., 2009)

Mutagen

Progenitor genotype

Associated Insertion(s)

P{PTT-un}Spc105R^P01511LE

Cytology

Description

Insertion in the first intron.

(Schittenhelm et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{PTT-un}

protein trap

Tagged with

EGFP

green fluorescent protein

Tag:polyHis

epitope tag

purification tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:20,800,675..20,800,675 [+]

(Schittenhelm et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle (with Df(3L)ri-XT1)

(Schittenhelm et al., 2009)

abnormal mitotic cell cycle (with Spc105R¹)

(Schittenhelm et al., 2009)

lethal | recessive

(Schittenhelm et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

More than 90% of anaphase/telophase figures are abnormal in mitosis 16 of Spc105R^P01511LE/Df(3L)ri-XT1 and Spc105R¹/Spc105R^P01511LE embryos.

(Schittenhelm et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Spc105R^P01511LE has lethal | recessive phenotype, suppressible by Spc105R::Dwil\Spc105R^wr15

(Schittenhelm et al., 2009)

Spc105R^P01511LE has lethal | recessive phenotype, suppressible by Spc105R::Dwil\Spc105R^wr30

(Schittenhelm et al., 2009)

Enhancer of

Statement

Reference

Spc105R[+]/Spc105R^P01511LE is an enhancer of visible phenotype of thr^{ΔC.GMR.Tag:MYC}

(Schittenhelm et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

Spc105R[+]/Spc105R^P01511LE is an enhancer of eye phenotype of thr^{ΔC.GMR.Tag:MYC}

(Schittenhelm et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Spc105R::Dwil\Spc105R^wr15 and Spc105R::Dwil\Spc105R^wr30 each promote the development of Spc105R^P01511LE hemizygotes to fertile adults.

(Schittenhelm et al., 2009)

Complementation and Rescue Data

Rescued by

Spc105R^P01511LE is rescued by Spc105R^+tg

(Schittenhelm et al., 2009)

Spc105R^P01511LE is rescued by Spc105R^C.EGFP

(Schittenhelm et al., 2009)

Spc105R^P01511LE is rescued by Spc105R^wr1

(Schittenhelm et al., 2009)

Partially rescued by

Spc105R^P01511LE/Spc105R¹ is partially rescued by Spc105R^wr1

(Schittenhelm et al., 2009)

Comments

Spc105R^+tg rescues both the recessive lethality and the dominant enhancement of the thr^{ΔC.GMR.T:Hsap\MYC} eye phenotype which is seen in Spc105R^P01511LE mutants.

Spc105R^wr1 promotes the development of Spc105R^P01511LE hemizygotes to fertile adults and almost completely rescues the abnormal anaphase/telophase figures seen during mitosis 16 in Spc105R¹/Spc105R^P01511LE embryos.

(Schittenhelm et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

50845

w^*; P{PTT-un}Spc105R^P01511LE/T(2;3)ap^Xa, ap^Xa

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Spc105²

(Schittenhelm et al., 2009)

Spc105R^P01511LE

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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