FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SlobUAS.cSa
Open Close
General Information
Symbol
Dmel\SlobUAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0243529
Feature type
allele
Associated gene
Dmel\Slob
Associated Insertion(s)
Carried in Construct
P{UAS-Slob.S}
Also Known As
UAS-slob57
Key Links
Transgenic product class
cDNA
(Shahidullah et al., 2009)
wild_type
(Shahidullah et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Shahidullah et al., 2009)
wild_type
(Shahidullah et al., 2009)
Mutagen
in vitro construct
(Shahidullah et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Slob.S}
Cytology
Description

UASt regulatory sequences drive expression of a full length Slob cDNA corresponding to the 57 kDa isoform.

(Shahidullah et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Slob
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared to wild-types, the conductance versus voltage (G-V) relationship is shifted in the depolarizing direction as a result of Scer\GAL4Ilp2.PR-driven expression of SlobScer\UAS.cSa in pars intercerebralis (PI-1) neurons.

      In contrast to wild-type controls, single slo channels in pars intercerebralis (PI-1) neurons appear to be closed most of the time, opening only occasionally and briefly in flies expressing Scer\GAL4Ilp2.PR-driven SlobScer\UAS.cSa.

      Compared to wild-type controls, action potential duration is increased in PI-1 neurons in flies in which transgenic SlobScer\UAS.cSa is expressed under the control of Scer\GAL4Ilp2.PR as a result of a change in the rate of repolarization.

      Compared to wild-types, the proportion of outward current blocked by the potassium channel blocker tetraethylammonium (TEA) is decreased in flies expressing Scer\GAL4cenB1A-Mai301-driven SlobScer\UAS.cSa.

      (Shahidullah et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act.PU/SlobUAS.cSa rescues Slobmut-IP1

      (Ma et al., 2011)

      Scer\GAL4insc-Mz1407/SlobUAS.cSa rescues Slobmut-IP1

      (Ma et al., 2011)

      Scer\GAL4CenB1A-Mai301/SlobUAS.cSa rescues SlobRNAi.UAS

      (Shahidullah et al., 2009)

      Scer\GAL4Ilp2.PR/SlobUAS.cSa rescues Slobmut-IP1

      (Shahidullah et al., 2009)
      Fails to rescue

      Scer\GAL4how-24B/SlobUAS.cSa fails to rescue Slobmut-IP1

      (Ma et al., 2011)
      Comments

      Expression of SlobScer\UAS.cSa under the control of either Scer\GAL4Act.PU or Scer\GAL41407 rescues the excitatory junctional current (EJC) peak amplitude of Slobmut-IP1 neuromuscular junctions to wild-type levels, and also restores the frequency and amplitude of spontaneous miniature mEJCs to normal.

      Expression of SlobScer\UAS.cSa under the control of Scer\GAL4how-24B does not rescue the electrophysiological defects at the Slobmut-IP1 neuromuscular junction.

      (Ma et al., 2011)

      The outward current phenotype observed in Slobmut-IP1 mutants is rescued by Scer\GAL4Ilp2.PR-driven expression of SlobScer\UAS.cSa.

      The outward current phenotype observed in mutants expressing SlobdsRNA.Scer\UAS under the control of Scer\GAL4cenB1A-Mai301 is rescued by co-expressing SlobScer\UAS.cSa.

      (Shahidullah et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SlobScer\UAS.cSa
      SlobUAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)